000135787 001__ 135787
000135787 005__ 20240614091948.0
000135787 0247_ $$2doi$$a10.1093/ckj/sfae140
000135787 0248_ $$2sideral$$a138814
000135787 037__ $$aART-2024-138814
000135787 041__ $$aeng
000135787 100__ $$aLlàcer, Pau
000135787 245__ $$aCongestion as a crucial factor determining albuminuria in patients with cardiorenal disease
000135787 260__ $$c2024
000135787 5060_ $$aAccess copy available to the general public$$fUnrestricted
000135787 5203_ $$aBackground: Albuminuria could potentially emerge as a novel marker of congestion in acute heart failure. However, the current evidence linking albuminuria and congestion in patients with congestive heart failure (CHF) remains somewhat scarce. This study aimed to evaluate the prevalence of albuminuria in a cohort of patients with CHF, identify the independent factors associated with albuminuria and analyse the correlation with different congestion parameters. Methods: This is a subanalysis of the Spanish Cardiorenal Registry, in which we enrolled 864 outpatients with heart failure and a value of urinary albumin:creatinine ratio (UACR) at the first visit. Results: The median age was 74 years, 549 (63.5%) were male and 438 (50.7%) had a reduced left ventricular ejection fraction. A total of 350 patients (40.5%) had albuminuria. Among these patients, 386 (33.1%) had a UACR of 30–300 mg/g and 64 (7.4%) had a UACR >300 mg/g. In order of importance, the independent variables associated with higher UACR were estimated glomerular filtration rate determined by the Chronic Kidney Disease Epidemiology Collaboration equation (R2 = 57.6%), systolic blood pressure (R2 = 21.1%), previous furosemide equivalent dose (FED; R2 = 7.5%), antigen carbohydrate 125 (CA125; R2 = 6.1%), diabetes mellitus (R2 = 5.6%) and oedema (R2 = 1.9%). The combined influence of oedema, elevated CA125 levels and the FED accounted for 15.5% of the model's variability. Conclusions: In patients with chronic stable heart failure, the prevalence of albuminuria is high. The risk factors of albuminuria in this population are chronic kidney disease and hypertension. Congestion parameters are also associated with increased albuminuria.
000135787 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000135787 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000135787 700__ $$aCobo Marcos, Marta
000135787 700__ $$ade la Espriella, Rafael
000135787 700__ $$aGayán Ordás, Jara
000135787 700__ $$aZegri, Isabel
000135787 700__ $$aFort, Aleix
000135787 700__ $$aRodríguez Chavarri, Adriana
000135787 700__ $$aMéndez, Ana
000135787 700__ $$aBlázquez, Zorba
000135787 700__ $$aCaravaca Pérez, Pedro
000135787 700__ $$0(orcid)0000-0002-4769-7154$$aRubio Gracia, Jorge$$uUniversidad de Zaragoza
000135787 700__ $$aFernández, Cristina
000135787 700__ $$aRecio-Mayoral, Alejandro
000135787 700__ $$aPomares, Antonia
000135787 700__ $$aGarcía Pinilla, Jose Manuel
000135787 700__ $$aVazquez López-Ibor, Jorge
000135787 700__ $$aCastro, Almudena
000135787 700__ $$aSoler, Maria Jose
000135787 700__ $$aGórriz, Jose Luis
000135787 700__ $$aBascompte Claret, Ramón
000135787 700__ $$aFluvià, Paula
000135787 700__ $$aManzano, Luis
000135787 700__ $$aNúñez, Julio
000135787 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000135787 773__ $$g17, 6 (2024), [10 pp.]$$pClin. kidney j.$$tClinical kidney journal$$x2048-8505
000135787 8564_ $$s899118$$uhttps://zaguan.unizar.es/record/135787/files/texto_completo.pdf$$yVersión publicada
000135787 8564_ $$s2500850$$uhttps://zaguan.unizar.es/record/135787/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000135787 909CO $$ooai:zaguan.unizar.es:135787$$particulos$$pdriver
000135787 951__ $$a2024-06-14-09:00:24
000135787 980__ $$aARTICLE