000135793 001__ 135793
000135793 005__ 20240614091948.0
000135793 0247_ $$2doi$$a10.1001/jamanetworkopen.2024.11852
000135793 0248_ $$2sideral$$a138781
000135793 037__ $$aART-2024-138781
000135793 041__ $$aeng
000135793 100__ $$aKhoury, Nadine
000135793 245__ $$aUltraprocessed Food Consumption and Cardiometabolic Risk Factors in Children
000135793 260__ $$c2024
000135793 5060_ $$aAccess copy available to the general public$$fUnrestricted
000135793 5203_ $$aHigh intake of ultraprocessed foods (UPFs) has been associated with higher cardiometabolic risk in adults; however, the evidence in children is limited.To investigate the association between UPF consumption and cardiometabolic risk factors in the Childhood Obesity Risk Assessment Longitudinal Study (CORALS).This baseline cross-sectional analysis was conducted using the data of CORALS participants recruited between March 22, 2019, and June 30, 2022. Preschool children (aged 3-6 years) were recruited from schools and centers in 7 cities in Spain. Inclusion criteria included informed consent signed by parents or caregivers and having a completed a set of questionnaires about the child’s prenatal history at home. Exclusion criteria included low command of Spanish or unstable residence.Energy-adjusted UPF consumption (in grams per day) from food frequency questionnaires and based on the NOVA food classification system.Age- and sex-specific z scores of adiposity parameters (body mass index [BMI], fat mass index, waist-to-height ratio, and waist circumference) and cardiometabolic parameters (diastolic and systolic blood pressure, fasting plasma glucose, homeostasis model assessment for insulin resistance, high-density and low-density lipoprotein cholesterol, and triglycerides) were estimated using linear regression models.Of 1509 enrolled CORALS participants, 1426 (mean [SD] age, 5.8 [1.1] years; 698 boys [49.0%]) were included in this study. Mothers of children with high UPF consumption were younger, had a higher BMI, were more likely to have overweight or obesity, and had lower education levels and employment rates. Compared with participants in the lowest tertile of energy-adjusted UPF consumption, those in the highest tertile showed higher z scores of BMI (β coefficient, 0.20; 95% CI, 0.05-0.35), waist circumference (β coefficient, 0.20; 95% CI, 0.05-0.35), fat mass index (β coefficient, 0.17; 95% CI, 0.00-0.32), and fasting plasma glucose (β coefficient, 0.22; 95% CI, 0.06-0.37) and lower z scores for HDL cholesterol (β coefficient, −0.19; 95% CI, −0.36 to −0.02). One-SD increments in energy-adjusted UPF consumption were associated with higher z scores for BMI (β coefficient, 0.11; 95% CI, 0.05-0.17), waist circumference (β coefficient, 0.09; 95% CI, 0.02-0.15), fat mass index (β coefficient, 0.11; 95% CI, 0.04-1.18), and fasting plasma glucose (β coefficient, 0.10; 95% CI, 0.03-0.17) and lower HDL cholesterol (β coefficient, −0.07; 95% CI, −0.15 to −0.00). Substituting 100 g of UPFs with 100 g of unprocessed or minimally processed foods was associated with lower z scores of BMI (β coefficient, −0.03; 95% CI, −0.06 to −0.01), fat mass index (β coefficient, −0.03; 95% CI, −0.06 to 0.00), and fasting plasma glucose (β coefficient, −0.04; 95% CI, −0.07 to −0.01).Conclusions and RelevanceThese findings suggest that high UPF consumption in young children is associated with adiposity and other cardiometabolic risk factors, highlighting the need for public health initiatives to promote the replacement of UPFs with unprocessed or minimally processed foods.
000135793 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000135793 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000135793 700__ $$aMartínez, María Ángeles
000135793 700__ $$aGarcidueñas-Fimbres, Tany E.
000135793 700__ $$aPastor-Villaescusa, Belén
000135793 700__ $$aLeis, Rosaura
000135793 700__ $$ade Las Heras-Delgado, Sara
000135793 700__ $$0(orcid)0000-0002-2411-9538$$aMiguel-Berges, María L.
000135793 700__ $$aNavas-Carretero, Santiago
000135793 700__ $$aPortoles, Olga
000135793 700__ $$aPérez-Vega, Karla Alejandra
000135793 700__ $$aJurado-Castro, Jose Manuel
000135793 700__ $$aVázquez-Cobela, Rocío
000135793 700__ $$aMimbrero, Gisela
000135793 700__ $$aAndía Horno, Raquel
000135793 700__ $$aMartínez, J. Alfredo
000135793 700__ $$aFlores-Rojas, Katherine
000135793 700__ $$aPicáns-Leis, Rosaura
000135793 700__ $$aLuque, Verónica
000135793 700__ $$0(orcid)0000-0003-0454-653X$$aMoreno, Luis A.$$uUniversidad de Zaragoza
000135793 700__ $$aCastro-Collado, Cristina
000135793 700__ $$aGil-Campos, Mercedes
000135793 700__ $$aSalas-Salvadó, Jordi
000135793 700__ $$aBabio, Nancy
000135793 7102_ $$11006$$2255$$aUniversidad de Zaragoza$$bDpto. Fisiatría y Enfermería$$cÁrea Enfermería
000135793 773__ $$g7, 5 (2024), 14 pp.$$pJAMA netw. open$$tJAMA network open$$x2574-3805
000135793 8564_ $$s1049854$$uhttps://zaguan.unizar.es/record/135793/files/texto_completo.pdf$$yVersión publicada
000135793 8564_ $$s2447426$$uhttps://zaguan.unizar.es/record/135793/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
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000135793 951__ $$a2024-06-14-09:00:31
000135793 980__ $$aARTICLE