000135919 001__ 135919 000135919 005__ 20240627150548.0 000135919 0247_ $$2doi$$a10.1007/s00216-024-05323-8 000135919 0248_ $$2sideral$$a138893 000135919 037__ $$aART-2024-138893 000135919 041__ $$aeng 000135919 100__ $$0(orcid)0000-0002-1532-3916$$aBen-Jeddou, Khaoula 000135919 245__ $$aNanosilver-based materials as feed additives: Evaluation of their transformations along in vitro gastrointestinal digestion in pigs and chickens by using an ICP-MS based analytical platform 000135919 260__ $$c2024 000135919 5060_ $$aAccess copy available to the general public$$fUnrestricted 000135919 5203_ $$aThe use of a new nanomaterial in the feed chain requires a risk assessment that involves in vitro gastrointestinal digestions to predict its degradation and oral exposure to nanoparticles. In this study, a nanosilver-based material was incorporated into pig and chicken feed as a growth-promoting additive and subjected to the corresponding in vitro gastrointestinal digestions. An inductively coupled plasma mass spectroscopy (ICP-MS) analytical platform was used to obtain information about the silver released in the different digestion phases. It included conventional ICP-MS for total silver determination, but also single particle ICP-MS and coupling to hydrodynamic chromatography for detection of dissolved and particulate silver. The bioaccessible fraction in the intestinal phase accounted for 8–13% of the total silver, mainly in the form of dissolved Ag(I) species, with less than 0.1% as silver-containing particles. Despite the additive behaving differently in pig and chicken digestions, the feed matrix played a relevant role in the fate of the silver. 000135919 536__ $$9info:eu-repo/grantAgreement/ES/DGA-FEDER/E29-23R$$9info:eu-repo/grantAgreement/EC/H2020/801586/EU/International Doctoral Programme for Talent Attraction to the Campus of International Excellence of the Ebro Valley/IberusTalent$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 801586-IberusTalent$$9info:eu-repo/grantAgreement/ES/MICINN/PID2021-123203OB-I00$$9info:eu-repo/grantAgreement/ES/NextGenerationEU/MZ-240621 000135919 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/ 000135919 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000135919 700__ $$0(orcid)0000-0002-8066-7117$$aBakir, Mariam 000135919 700__ $$0(orcid)0000-0002-8460-6020$$aJiménez, María S.$$uUniversidad de Zaragoza 000135919 700__ $$0(orcid)0000-0003-1400-9041$$aGómez, María T.$$uUniversidad de Zaragoza 000135919 700__ $$0(orcid)0000-0002-7931-3901$$aAbad-Álvaro, Isabel$$uUniversidad de Zaragoza 000135919 700__ $$0(orcid)0000-0002-4169-0357$$aLaborda, Francisco$$uUniversidad de Zaragoza 000135919 7102_ $$12009$$2750$$aUniversidad de Zaragoza$$bDpto. Química Analítica$$cÁrea Química Analítica 000135919 773__ $$g416 (2024), 3821-3833$$pAnal. Bioanal. Chem.$$tAnalytical and Bioanalytical Chemistry$$x1618-2642 000135919 8564_ $$s1560395$$uhttps://zaguan.unizar.es/record/135919/files/texto_completo.pdf$$yVersión publicada 000135919 8564_ $$s2456954$$uhttps://zaguan.unizar.es/record/135919/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000135919 909CO $$ooai:zaguan.unizar.es:135919$$particulos$$pdriver 000135919 951__ $$a2024-06-27-13:20:39 000135919 980__ $$aARTICLE