135919 20260217205542.0 doi 10.1007/s00216-024-05323-8 sideral 138893 ART-2024-138893 eng Ben-Jeddou, Khaoula (orcid)0000-0002-1532-3916 Nanosilver-based materials as feed additives: Evaluation of their transformations along in vitro gastrointestinal digestion in pigs and chickens by using an ICP-MS based analytical platform 2024 Access copy available to the general public Unrestricted The use of a new nanomaterial in the feed chain requires a risk assessment that involves in vitro gastrointestinal digestions to predict its degradation and oral exposure to nanoparticles. In this study, a nanosilver-based material was incorporated into pig and chicken feed as a growth-promoting additive and subjected to the corresponding in vitro gastrointestinal digestions. An inductively coupled plasma mass spectroscopy (ICP-MS) analytical platform was used to obtain information about the silver released in the different digestion phases. It included conventional ICP-MS for total silver determination, but also single particle ICP-MS and coupling to hydrodynamic chromatography for detection of dissolved and particulate silver. The bioaccessible fraction in the intestinal phase accounted for 8–13% of the total silver, mainly in the form of dissolved Ag(I) species, with less than 0.1% as silver-containing particles. Despite the additive behaving differently in pig and chicken digestions, the feed matrix played a relevant role in the fate of the silver. info:eu-repo/grantAgreement/ES/DGA-FEDER/E29-23R info:eu-repo/grantAgreement/EC/H2020/801586/EU/International Doctoral Programme for Talent Attraction to the Campus of International Excellence of the Ebro Valley/IberusTalent This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 801586-IberusTalent info:eu-repo/grantAgreement/ES/MICINN/PID2021-123203OB-I00 info:eu-repo/grantAgreement/ES/NextGenerationEU/MZ-240621 info:eu-repo/semantics/openAccess by https://creativecommons.org/licenses/by/4.0/deed.es 3.8 2024 BIOCHEMICAL RESEARCH METHODS 21 / 86 = 0.244 2024 Q1 T1 CHEMISTRY, ANALYTICAL 31 / 111 = 0.279 2024 Q2 T1 0.716 2024 Biochemistry 2024 Q2 Analytical Chemistry 2024 Q2 7.9 2024 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Bakir, Mariam (orcid)0000-0002-8066-7117 Jiménez, María S. Universidad de Zaragoza (orcid)0000-0002-8460-6020 Gómez, María T. Universidad de Zaragoza (orcid)0000-0003-1400-9041 Abad-Álvaro, Isabel Universidad de Zaragoza (orcid)0000-0002-7931-3901 Laborda, Francisco Universidad de Zaragoza (orcid)0000-0002-4169-0357 2009 750 Universidad de Zaragoza Dpto. Química Analítica Área Química Analítica 416 (2024), 3821-3833 Anal. Bioanal. Chem. Analytical and Bioanalytical Chemistry 1618-2642 1560395 http://zaguan.unizar.es/record/135919/files/texto_completo.pdf Versión publicada 2456954 http://zaguan.unizar.es/record/135919/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:135919 articulos driver 2026-02-17-20:36:54 ARTICLE