000135924 001__ 135924
000135924 005__ 20240627150548.0
000135924 0247_ $$2doi$$a10.1039/d4re00107a
000135924 0248_ $$2sideral$$a138950
000135924 037__ $$aART-2024-138950
000135924 041__ $$aeng
000135924 100__ $$aUdepurkar, Aniket Pradip
000135924 245__ $$aMicrofluidic synthesis of PLGA nanoparticles enabled by an ultrasonic microreactor
000135924 260__ $$c2024
000135924 5060_ $$aAccess copy available to the general public$$fUnrestricted
000135924 5203_ $$aWe present an ultrasonic microreactor for synthesising poly(lactic-co-glycolic) acid (PLGA) nanoparticles through the emulsion-solvent evaporation technique. Monodispersed PLGA nanoparticles (polydispersity index (PDI) < 0.3) in the size range of 20-300 nm are desired for biomedical applications. An ultrasonic microreactor with rough microchannels is utilised for the synthesis of PLGA nanoparticles. Through a comprehensive parametric investigation, we identify the optimal ultrasonic power, PLGA concentration, and aqueous-to-organic phase flow rate ratio, to minimise the size of the PLGA nanoparticles. By varying the operational parameters and the concentration of PLGA, the mean hydrodynamic diameter of the monodispersed PLGA nanoparticles (PDI of 0.1-0.2) can be varied within the range of 115-150 nm. Furthermore, the successful encapsulation of a hydrophobic dye, Nile Red, is demonstrated, where a dye loading (DL) of up to 0.34% is achieved, which is in agreement with the previously reported loading of Nile Red. The in vitro release study performed for the Nile Red-loaded PLGA nanoparticles (NR-PLGA) reveals a triphasic release profile of Nile Red. In summary, this work highlights the potential of the ultrasonic microreactor as a versatile platform for the synthesis of PLGA nanoparticles suitable for biomedical applications.
000135924 536__ $$9info:eu-repo/grantAgreement/ES/MICINN/PDC2022-133866-I00$$9info:eu-repo/grantAgreement/ES/MINECO/PID2021-127847OB-I00
000135924 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc$$uhttp://creativecommons.org/licenses/by-nc/3.0/es/
000135924 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000135924 700__ $$aMampaey, Laura
000135924 700__ $$aClasen, Christian
000135924 700__ $$0(orcid)0000-0002-6873-5244$$aSebastián Cabeza, Víctor$$uUniversidad de Zaragoza
000135924 700__ $$aKuhn, Simon
000135924 7102_ $$15005$$2555$$aUniversidad de Zaragoza$$bDpto. Ing.Quím.Tecnol.Med.Amb.$$cÁrea Ingeniería Química
000135924 773__ $$g(2024), [10 pp.]$$pReact. chem. eng.$$tReaction Chemistry & Engineering$$x2058-9883
000135924 8564_ $$s1732518$$uhttps://zaguan.unizar.es/record/135924/files/texto_completo.pdf$$yVersión publicada
000135924 8564_ $$s2823993$$uhttps://zaguan.unizar.es/record/135924/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000135924 909CO $$ooai:zaguan.unizar.es:135924$$particulos$$pdriver
000135924 951__ $$a2024-06-27-13:20:45
000135924 980__ $$aARTICLE