000135933 001__ 135933
000135933 005__ 20240627150549.0
000135933 0247_ $$2doi$$a10.1007/s13105-024-01029-8
000135933 0248_ $$2sideral$$a138935
000135933 037__ $$aART-2024-138935
000135933 041__ $$aeng
000135933 100__ $$0(orcid)0000-0002-8100-5596$$aMartínez-Beamonte, Roberto$$uUniversidad de Zaragoza
000135933 245__ $$aEffect of virgin olive oil as spreadable preparation on atherosclerosis compared to dairy butter in Apoe-deficient mice
000135933 260__ $$c2024
000135933 5060_ $$aAccess copy available to the general public$$fUnrestricted
000135933 5203_ $$aOlive oil is the main source of lipid energy in the Mediterranean diet and there is strong evidence of its health benefits. The effect of extra virgin olive oil (EVOO) in the form of a preparation of spreadable virgin olive oil (S-VO) on the progression of atheroma plaques was investigated in Apoe-deficient mice, a model of accelerated atherosclerosis. Methods: Two isocaloric Western purified diets containing 20% fat, either as S-VO or as dairy butter, were used to feed 28 males and 16 females of two-month-old Apoe-deficient mice for 12 weeks. S-VO was prepared by blending more than 75% virgin olive oil with other vegetal natural fat to obtain a solid fat. Plasma total cholesterol, triglycerides and HDL cholesterol were measured. Hepatic lipid droplets were analyzed. Areas of atherosclerotic aortic lesions were quantified in cross-sectional images of the proximal aorta and en face analysis of the whole aorta. Results: Total plasma cholesterol was increased in mice on the butter-supplemented diet in both female and male mice compared to S-VO, and the ratio of TC/HDL-cholesterol was significantly lower in S-VO than in the butter diet, although only in males, and no differences in plasma triglycerides were observed. No significant differences in hepatic lipid droplets were observed between diets in either sex. Aortic lesion areas were significantly higher in mice consuming the butter versus the S-VO diet in both sexes. Conclusion: Extra virgin olive oil prepared in spreadable form maintained the delay in atheroma plaque progression compared to butter.
000135933 536__ $$9info:eu-repo/grantAgreement/ES/CIBERObn/CB06-03-1012$$9info:eu-repo/grantAgreement/ES/DGA/B16-23R$$9info:eu-repo/grantAgreement/ES/MICINN AEI/PID2022-1364140B- I00$$9info:eu-repo/grantAgreement/ES/MICINN-ISCIIII-FEDER/PID2019-104915RB-I00
000135933 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000135933 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000135933 700__ $$0(orcid)0000-0002-8442-8041$$aBarranquero, Cristina
000135933 700__ $$aGascón, Sonia
000135933 700__ $$aMariño, Juan
000135933 700__ $$0(orcid)0000-0002-5152-1071$$aArnal, Carmen
000135933 700__ $$aEstopañán, Gloria
000135933 700__ $$0(orcid)0000-0002-3595-7668$$aRodriguez-Yoldi, María Jesús$$uUniversidad de Zaragoza
000135933 700__ $$0(orcid)0000-0002-5841-0462$$aSurra, Joaquín Carlos$$uUniversidad de Zaragoza
000135933 700__ $$aMartín-Belloso, Olga
000135933 700__ $$aOdriozola-Serrano, Isabel
000135933 700__ $$aOrman, Israel
000135933 700__ $$aSegovia, Jose Carlos
000135933 700__ $$0(orcid)0000-0002-8251-8457$$aOsada, Jesús$$uUniversidad de Zaragoza
000135933 700__ $$0(orcid)0000-0002-0108-1004$$aNavarro, María Ángeles$$uUniversidad de Zaragoza
000135933 7102_ $$11012$$2410$$aUniversidad de Zaragoza$$bDpto. Farmac.Fisiol.y Med.L.F.$$cÁrea Fisiología
000135933 7102_ $$12008$$2700$$aUniversidad de Zaragoza$$bDpto. Produc.Animal Cienc.Ali.$$cÁrea Producción Animal
000135933 7102_ $$11002$$2060$$aUniversidad de Zaragoza$$bDpto. Bioq.Biolog.Mol. Celular$$cÁrea Bioquímica y Biolog.Mole.
000135933 7102_ $$11002$$2050$$aUniversidad de Zaragoza$$bDpto. Bioq.Biolog.Mol. Celular$$cÁrea Biología Celular
000135933 773__ $$g(2024), [13 pp.]$$pJ. physiol. biochem.$$tJournal of Physiology and Biochemistry$$x1138-7548
000135933 8564_ $$s1738316$$uhttps://zaguan.unizar.es/record/135933/files/texto_completo.pdf$$yVersión publicada
000135933 8564_ $$s2588490$$uhttps://zaguan.unizar.es/record/135933/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000135933 909CO $$ooai:zaguan.unizar.es:135933$$particulos$$pdriver
000135933 951__ $$a2024-06-27-13:20:54
000135933 980__ $$aARTICLE