000135983 001__ 135983
000135983 005__ 20260218073524.0
000135983 0247_ $$2doi$$a10.1111/aos.16721
000135983 0248_ $$2sideral$$a138996
000135983 037__ $$aART-2024-138996
000135983 041__ $$aeng
000135983 100__ $$aAlluyn, Lien
000135983 245__ $$aAnterior scleral thickness in Marfan syndrome: A quantitative analysis
000135983 260__ $$c2024
000135983 5060_ $$aAccess copy available to the general public$$fUnrestricted
000135983 5203_ $$aPurpose: To investigate the anterior scleral thickness (AST) in patients with Marfan syndrome (MFS). Methods: A prospective, cross-sectional study was conducted at the Department of Ophthalmology, Ghent University Hospital, Ghent, including patients with a genetically confirmed clinical diagnosis of MFS and age-, gender- and axial length-matched controls. Subjects with known corneal, conjunctival or scleral pathology and a history of ocular surgery, including pars plana vitrectomy, recent contact lens use or high-grade astigmatism were excluded. Subjects underwent non-cycloplegic autorefraction, Scheimpflug-based corneal tomography, axial length measurement and spectral-domain optical coherence tomography (OCT). AST was manually measured at 1 mm (AST1), 2 mm (AST2) and 3 mm (AST3) from the scleral spur, temporally and nasally. Results: A total of 56 subjects (28 subjects in the MFS group and 28 matched subjects in the control group) were included in this study. In patients with MFS, AST was significantly reduced compared to matched controls, both overall and at every analysed measuring point in the nasal and temporal areas (p < 0.001). Central corneal thickness (CCT) and mean keratometry (Kmean) values were significantly lower in patients with MFS (p < 0.05). A positive correlation was found between nasal AST and CCT in patients with MFS. No correlation was found between AST and Kmean or between AST and axial length. In patients with MFS with ectopia lentis, compared to those without, temporal AST3 was significantly lower (p < 0.05). AST was significantly lower in patients with MFS harbouring a variant predicted to cause haploinsufficiency compared to those with a variant expected to lead to a dominant negative effect for both nasal and temporal measurements. Conclusion: Based on anterior segment OCT measurements, AST of patients with MFS is significantly lower compared to matched controls.
000135983 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000135983 590__ $$a2.8$$b2024
000135983 592__ $$a1.393$$b2024
000135983 591__ $$aOPHTHALMOLOGY$$b23 / 99 = 0.232$$c2024$$dQ1$$eT1
000135983 593__ $$aOphthalmology$$c2024$$dQ1
000135983 593__ $$aMedicine (miscellaneous)$$c2024$$dQ1
000135983 594__ $$a7.3$$b2024
000135983 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000135983 700__ $$aDequeker, Laure
000135983 700__ $$aDhaese, Siska
000135983 700__ $$0(orcid)0000-0001-5186-1837$$aConsejo, Alejandra$$uUniversidad de Zaragoza
000135983 700__ $$aDe Zaeytijd, Julie
000135983 700__ $$aLeroy, Bart P.
000135983 700__ $$aDe Backer, Julie
000135983 700__ $$aKreps, Elke O.
000135983 7102_ $$12002$$2385$$aUniversidad de Zaragoza$$bDpto. Física Aplicada$$cÁrea Física Aplicada
000135983 773__ $$g102, 7 (2024), e1050-e1056$$pActa ophthamol.$$tACTA OPHTHALMOLOGICA$$x1755-375X
000135983 8564_ $$s806722$$uhttps://zaguan.unizar.es/record/135983/files/texto_completo.pdf$$yPostprint$$zinfo:eu-repo/date/embargoEnd/2025-05-21
000135983 8564_ $$s895002$$uhttps://zaguan.unizar.es/record/135983/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint$$zinfo:eu-repo/date/embargoEnd/2025-05-21
000135983 909CO $$ooai:zaguan.unizar.es:135983$$particulos$$pdriver
000135983 951__ $$a2026-02-17-20:37:18
000135983 980__ $$aARTICLE