Thermophysical properties of lidocaine:thymol or l-menthol eutectic mixtures
Molero Sangüesa, María ; Jiménez Omeñaca, Isabel ; Bergua, Fernando (Universidad de Zaragoza) ; Artigas, Héctor (Universidad de Zaragoza) ; Lafuente, Carlos (Universidad de Zaragoza) ; Artal, Manuela (Universidad de Zaragoza)
Resumen: Backgrounds
A key objective of green chemistry is to obtain a broad database of thermophysical properties of liquid mixtures. Thus, the replacement of conventional solvents with ecological ones will be facilitated.
Methods
Herein, two eutectic systems with therapeutic properties are characterized. They are binary mixtures of lidocaine and thymol or l-menthol. Properties as solid-liquid equilibrium, density, speed of sound, refractive index, isobaric molar heat capacity, surface tension, and viscosity were determined at 0.1 MPa and several temperatures. From them, others derivatives were calculated. In addition, the phase diagram was correlated with NRTL model and the density and isobaric molar heat capacity were modelled with PC-SAFT equation of state.
Significant findings
Although the mixtures with l-menthol were almost ideal, a complex diagram owing the presence of stable and metastable phases. For these mixtures, the values of all measured properties were lower than those with thymol. Results indicated that PC-SAFT can be used to predict the thermodynamic behaviour of both systems in any working condition.
Idioma: Inglés
DOI: 10.1016/j.jtice.2024.105631
Año: 2024
Publicado en: Journal of the Taiwan Institute of Chemical Engineers 163 (2024), 105631 [9 pp.]
ISSN: 1876-1070
Financiación: info:eu-repo/grantAgreement/ES/DGA/E31-23R
Tipo y forma: Artículo (Versión definitiva)
Área (Departamento): Área Química Física (Dpto. Química Física)
Debe reconocer adecuadamente la autoría, proporcionar un enlace a la licencia e indicar si se han realizado cambios. Puede hacerlo de cualquier manera razonable, pero no de una manera que sugiera que tiene el apoyo del licenciador o lo recibe por el uso que hace. No puede utilizar el material para una finalidad comercial. Si remezcla, transforma o crea a partir del material, no puede difundir el material modificado.
Exportado de SIDERAL (2024-07-04-07:59:35)
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A key objective of green chemistry is to obtain a broad database of thermophysical properties of liquid mixtures. Thus, the replacement of conventional solvents with ecological ones will be facilitated.
Methods
Herein, two eutectic systems with therapeutic properties are characterized. They are binary mixtures of lidocaine and thymol or l-menthol. Properties as solid-liquid equilibrium, density, speed of sound, refractive index, isobaric molar heat capacity, surface tension, and viscosity were determined at 0.1 MPa and several temperatures. From them, others derivatives were calculated. In addition, the phase diagram was correlated with NRTL model and the density and isobaric molar heat capacity were modelled with PC-SAFT equation of state.
Significant findings
Although the mixtures with l-menthol were almost ideal, a complex diagram owing the presence of stable and metastable phases. For these mixtures, the values of all measured properties were lower than those with thymol. Results indicated that PC-SAFT can be used to predict the thermodynamic behaviour of both systems in any working condition.
Idioma: Inglés
DOI: 10.1016/j.jtice.2024.105631
Año: 2024
Publicado en: Journal of the Taiwan Institute of Chemical Engineers 163 (2024), 105631 [9 pp.]
ISSN: 1876-1070
Financiación: info:eu-repo/grantAgreement/ES/DGA/E31-23R
Tipo y forma: Artículo (Versión definitiva)
Área (Departamento): Área Química Física (Dpto. Química Física)
Debe reconocer adecuadamente la autoría, proporcionar un enlace a la licencia e indicar si se han realizado cambios. Puede hacerlo de cualquier manera razonable, pero no de una manera que sugiera que tiene el apoyo del licenciador o lo recibe por el uso que hace. No puede utilizar el material para una finalidad comercial. Si remezcla, transforma o crea a partir del material, no puede difundir el material modificado.Exportado de SIDERAL (2024-07-04-07:59:35)
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Registro creado el 2024-07-04, última modificación el 2024-07-04