000136080 001__ 136080
000136080 005__ 20250923084430.0
000136080 0247_ $$2doi$$a10.3390/photonics11060524
000136080 0248_ $$2sideral$$a139043
000136080 037__ $$aART-2024-139043
000136080 041__ $$aeng
000136080 100__ $$0(orcid)0000-0002-9068-7728$$aÁvila, Francisco J.$$uUniversidad de Zaragoza
000136080 245__ $$aA Comprehensive Study on Elasticity and Viscosity in Biomechanics and Optical Properties of the Living Human Cornea
000136080 260__ $$c2024
000136080 5060_ $$aAccess copy available to the general public$$fUnrestricted
000136080 5203_ $$aCorneal biomechanics is a hot topic in ophthalmology. The biomechanical properties (BMPs) of the cornea have important implications in the management and diagnosis of corneal diseases such as ectasia and keratoconus. In addition, the characterization of BMPs is crucial to model the predictability of a corneal surgery intervention, the outcomes of refractive surgery or the follow-up of corneal diseases. The biomechanical behavior of the cornea is governed by viscoelastic properties that allow, among other structural implications, the damping of excess intraocular pressure and the reduction of damage to the optic nerve. Currently, the most versatile and complete methods to measure corneal viscoelasticity are based on air-puff corneal applanation. However, these methods lack the ability to directly measure corneal viscosity. The aim of this work is to propose a new methodology based on the analysis of corneal air-puff measurements through the standard linear solid model (SLSM) to provide analytical expressions to separately calculate the elastic and time-dependent (corneal retardation time and viscosity) properties. The results show the mean values of elasticity (E), viscosity (Ƞ) and corneal retardation time (τ) in a sample of 200 young and healthy subjects. The influence of elasticity and viscosity on viscoelasticity, high-order corneal aberrations and optical transparency is investigated. Finally, the SLSM fed back from experimental E and Ƞ values is employed to compare the creep relaxation response between a normal, an ocular hypertension patient and an Ortho-K user. Corneal biomechanics is strongly affected by intraocular pressure (IOP); however, corneal hysteresis (CH) analysis is not enough to be employed as a risk factor of glaucoma progression. Low values of CH can be accompanied by high or low corneal elasticity and viscosity depending on the IOP threshold from which the time-dependent biomechanical properties trends are reversed.
000136080 536__ $$9info:eu-repo/grantAgreement/ES/DGA-FEDER/E44-23R
000136080 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000136080 590__ $$a1.9$$b2024
000136080 592__ $$a0.459$$b2024
000136080 591__ $$aOPTICS$$b77 / 125 = 0.616$$c2024$$dQ3$$eT2
000136080 593__ $$aAtomic and Molecular Physics, and Optics$$c2024$$dQ2
000136080 593__ $$aInstrumentation$$c2024$$dQ2
000136080 593__ $$aRadiology, Nuclear Medicine and Imaging$$c2024$$dQ3
000136080 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000136080 700__ $$adel Barco, Óscar
000136080 700__ $$0(orcid)0000-0002-7516-3029$$aMarcellán, María Concepción$$uUniversidad de Zaragoza
000136080 700__ $$0(orcid)0000-0002-3979-4528$$aRemón, Laura$$uUniversidad de Zaragoza
000136080 7102_ $$12002$$2647$$aUniversidad de Zaragoza$$bDpto. Física Aplicada$$cÁrea Óptica
000136080 773__ $$g11, 6 (2024), 524$$pPhotonics (Basel)$$tPhotonics$$x2304-6732
000136080 8564_ $$s5383949$$uhttps://zaguan.unizar.es/record/136080/files/texto_completo.pdf$$yVersión publicada
000136080 8564_ $$s2618360$$uhttps://zaguan.unizar.es/record/136080/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000136080 909CO $$ooai:zaguan.unizar.es:136080$$particulos$$pdriver
000136080 951__ $$a2025-09-22-14:42:41
000136080 980__ $$aARTICLE