000136087 001__ 136087
000136087 005__ 20250908131425.0
000136087 0247_ $$2doi$$a10.1093/jacamr/dlae087
000136087 0248_ $$2sideral$$a139059
000136087 037__ $$aART-2024-139059
000136087 041__ $$aeng
000136087 100__ $$aRodríguez-Villodres, Ángel
000136087 245__ $$aActivity of cefepime, carbapenems and new ß-lactam/ß-lactamase inhibitor combinations on Enterobacter cloacae complex and Klebsiella aerogenes in Spain (SMART 2016–2022)
000136087 260__ $$c2024
000136087 5060_ $$aAccess copy available to the general public$$fUnrestricted
000136087 5203_ $$aObjectives
To analyse the susceptibility profile to cefepime, carbapenems and new β-lactam/β-lactamase inhibitor combinations in Enterobacter cloacae complex and Klebsiella aerogenes isolated from intra-abdominal, urinary, respiratory and bloodstream infections in the SMART (Study for Monitoring Antimicrobial Resistance Trends) surveillance study in Spain.
Methods
The susceptibilities of 759 isolates (473 E. cloacae complex and 286 K. aerogenes) collected in 11 Spanish hospitals from 2016 to 2022 were analysed following the EUCAST 2023 criteria. Molecular characterization looking for β-lactamase genes was performed through PCR and DNA sequencing analysis.
Results
E. cloacae complex showed resistance to third-generation cephalosporins in 25% of the cases, whereas K. aerogenes was resistant in 35%. Regarding cefepime, resistance in E. cloacae was higher (10%) than in K. aerogenes (2%). Carbapenems showed >85% activity in both microorganisms. Ceftazidime/avibactam, imipenem/relebactam and meropenem/vaborbactam had good activity against these microorganisms (>95%). In contrast, the activity of ceftolozane/tazobactam was lower (80%). A high proportion of the isolates resistant to new β-lactam/β-lactamase inhibitor combinations carried a carbapenemase, mainly OXA-48-like and VIM-1.
Conclusions
Ceftazidime/avibactam, imipenem/relebactam and meropenem/vaborbactam show high activity against both E. cloacae complex and K. aerogenes isolates recovered in the SMART-Spain study. In contrast, differences have been found in the case of cefepime, showing more activity against K. aerogenes than E. cloacae complex. These results are useful for antimicrobial stewardship programmes and for the implementation of local and national guidelines.
000136087 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000136087 592__ $$a1.063$$b2024
000136087 593__ $$aInfectious Diseases$$c2024$$dQ1
000136087 593__ $$aMicrobiology (medical)$$c2024$$dQ1
000136087 593__ $$aMicrobiology$$c2024$$dQ2
000136087 593__ $$aImmunology and Allergy$$c2024$$dQ2
000136087 593__ $$aImmunology$$c2024$$dQ2
000136087 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000136087 700__ $$aLepe-Balsalobre, Esperanza
000136087 700__ $$aOrtiz De La Rosa, José Manuel
000136087 700__ $$aGiner Almaraz, Salvador
000136087 700__ $$aGonzález De Herrero, Elisa
000136087 700__ $$aCercenado, Emilia
000136087 700__ $$aGarcía-Fernández, Sergio
000136087 700__ $$0(orcid)0000-0001-5134-1006$$aBenito, Rafael$$uUniversidad de Zaragoza
000136087 700__ $$aPonz Mir, Ricardo
000136087 700__ $$aCantón, Rafael
000136087 700__ $$aLepe, José Antonio
000136087 7102_ $$11011$$2630$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cÁrea Microbiología
000136087 773__ $$g6, 3 (2024), 1-6$$tJAC-antimicrobial resistance$$x2632-1823
000136087 8564_ $$s383371$$uhttps://zaguan.unizar.es/record/136087/files/texto_completo.pdf$$yVersión publicada
000136087 8564_ $$s2959848$$uhttps://zaguan.unizar.es/record/136087/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000136087 909CO $$ooai:zaguan.unizar.es:136087$$particulos$$pdriver
000136087 951__ $$a2025-09-08-12:54:10
000136087 980__ $$aARTICLE