000136101 001__ 136101
000136101 005__ 20240711103551.0
000136101 0247_ $$2doi$$a10.3390/nu16111599
000136101 0248_ $$2sideral$$a139030
000136101 037__ $$aART-2024-139030
000136101 041__ $$aeng
000136101 100__ $$aTorrijo-Belanche, Carolina
000136101 245__ $$aHigh Serum Phosphate Is Associated with Cardiovascular Mortality and Subclinical Coronary Atherosclerosis: Systematic Review and Meta-Analysis
000136101 260__ $$c2024
000136101 5060_ $$aAccess copy available to the general public$$fUnrestricted
000136101 5203_ $$a(1) Background: Cardiovascular diseases (CVDs) are the leading cause of mortality worldwide. The aim of the study was to examine the existing published results of the association between elevated serum phosphate concentrations and cardiovascular mortality, along with the CVD incidence and subclinical coronary atherosclerosis, in primary prevention among non-selected samples of the general population. (2) Methods: A systematic review and meta-analysis were carried out using literature obtained from PubMed, SCOPUS, and the Web Of Science until March 2024 and following the PRISMA guidelines. Relevant information was extracted and presented. Random and fixed effects models were used to estimate the pooled odds ratio (OR) and hazard ratio (HR) with their 95% coefficient interval (CI), and I2 was used to assess heterogeneity. (3) Results: Twenty-five studies met our inclusion criteria and were included in the meta-analysis (11 cross-sectional and 14 cohort studies). For cardiovascular mortality, which included 7 cohort studies and 41,764 adults, the pooled HR was 1.44 (95% CIs 1.28, 1.61; I2 0%) when the highest versus the reference level of serum phosphate concentrations were compared. For CVDs, which included 8 cohort studies and 61,723 adults, the pooled HR was 1.12 (95% CIs 0.99, 1.27; I2 51%). For subclinical coronary atherosclerosis, which included 11 cross-sectional studies and 24,820 adults, the pooled OR was 1.44 (95% CIs 1.15, 1.79; I2 88%). (4) Conclusions: The highest serum phosphate concentrations were positively associated with a 44% increased risk of cardiovascular mortality and subclinical coronary atherosclerosis.
000136101 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI20-144$$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI19-00948
000136101 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000136101 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000136101 700__ $$0(orcid)0000-0003-0604-5042$$aMoreno-Franco, Belén$$uUniversidad de Zaragoza
000136101 700__ $$aMuñoz-Cabrejas, Ainara
000136101 700__ $$0(orcid)0000-0002-1889-3746$$aCalvo-Galiano, Naiara$$uUniversidad de Zaragoza
000136101 700__ $$0(orcid)0000-0002-9887-2629$$aCasasnovas, José Antonio$$uUniversidad de Zaragoza
000136101 700__ $$aSayón-Orea, Carmen
000136101 700__ $$aGuallar-Castillón, Pilar
000136101 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000136101 7102_ $$11011$$2615$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cÁrea Medic.Prevent.Salud Públ.
000136101 773__ $$g16, 11 (2024), 1599$$pNutrients$$tNutrients$$x2072-6643
000136101 8564_ $$s1560456$$uhttps://zaguan.unizar.es/record/136101/files/texto_completo.pdf$$yVersión publicada
000136101 8564_ $$s2754623$$uhttps://zaguan.unizar.es/record/136101/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000136101 909CO $$ooai:zaguan.unizar.es:136101$$particulos$$pdriver
000136101 951__ $$a2024-07-11-08:38:21
000136101 980__ $$aARTICLE