136101 20260217205547.0 doi 10.3390/nu16111599 sideral 139030 ART-2024-139030 eng Torrijo-Belanche, Carolina High Serum Phosphate Is Associated with Cardiovascular Mortality and Subclinical Coronary Atherosclerosis: Systematic Review and Meta-Analysis 2024 Access copy available to the general public Unrestricted (1) Background: Cardiovascular diseases (CVDs) are the leading cause of mortality worldwide. The aim of the study was to examine the existing published results of the association between elevated serum phosphate concentrations and cardiovascular mortality, along with the CVD incidence and subclinical coronary atherosclerosis, in primary prevention among non-selected samples of the general population. (2) Methods: A systematic review and meta-analysis were carried out using literature obtained from PubMed, SCOPUS, and the Web Of Science until March 2024 and following the PRISMA guidelines. Relevant information was extracted and presented. Random and fixed effects models were used to estimate the pooled odds ratio (OR) and hazard ratio (HR) with their 95% coefficient interval (CI), and I2 was used to assess heterogeneity. (3) Results: Twenty-five studies met our inclusion criteria and were included in the meta-analysis (11 cross-sectional and 14 cohort studies). For cardiovascular mortality, which included 7 cohort studies and 41,764 adults, the pooled HR was 1.44 (95% CIs 1.28, 1.61; I2 0%) when the highest versus the reference level of serum phosphate concentrations were compared. For CVDs, which included 8 cohort studies and 61,723 adults, the pooled HR was 1.12 (95% CIs 0.99, 1.27; I2 51%). For subclinical coronary atherosclerosis, which included 11 cross-sectional studies and 24,820 adults, the pooled OR was 1.44 (95% CIs 1.15, 1.79; I2 88%). (4) Conclusions: The highest serum phosphate concentrations were positively associated with a 44% increased risk of cardiovascular mortality and subclinical coronary atherosclerosis. info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI20-144 info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI19-00948 info:eu-repo/semantics/openAccess by https://creativecommons.org/licenses/by/4.0/deed.es 5.0 2024 NUTRITION & DIETETICS 17 / 113 = 0.15 2024 Q1 T1 1.473 2024 Nutrition and Dietetics 2024 Q1 Food Science 2024 Q1 9.1 2024 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Moreno-Franco, Belén Universidad de Zaragoza (orcid)0000-0003-0604-5042 Muñoz-Cabrejas, Ainara Calvo-Galiano, Naiara Universidad de Zaragoza (orcid)0000-0002-1889-3746 Casasnovas, José Antonio Universidad de Zaragoza (orcid)0000-0002-9887-2629 Sayón-Orea, Carmen Guallar-Castillón, Pilar 1007 610 Universidad de Zaragoza Dpto. Medicina, Psiqu. y Derm. Area Medicina 1011 615 Universidad de Zaragoza Dpto. Microb.Ped.Radio.Sal.Pú. Área Medic.Prevent.Salud Públ. 16, 11 (2024), 1599 Nutrients Nutrients 2072-6643 1560456 http://zaguan.unizar.es/record/136101/files/texto_completo.pdf Versión publicada 2754623 http://zaguan.unizar.es/record/136101/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:136101 articulos driver 2026-02-17-20:38:39 ARTICLE