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000136116 001__ 136116 000136116 005__ 20250923084428.0 000136116 0247_ $$2doi$$a10.3390/biom14060718 000136116 0248_ $$2sideral$$a139052 000136116 037__ $$aART-2024-139052 000136116 041__ $$aeng 000136116 100__ $$aPadoan, F. 000136116 245__ $$aThe role of Zinc in developed countries in pediatric patients: a 360-degree view 000136116 260__ $$c2024 000136116 5060_ $$aAccess copy available to the general public$$fUnrestricted 000136116 5203_ $$aZinc is an important trace element for growth and health at pediatric ages. Zinc is fundamental in inflammatory pathways, oxidative balance, and immune function. Zinc exhibits anti-inflammatory properties by modulating Nuclear Factor-kappa (NF-κB) activity and reducing histamine release from basophils, leukocytes, and mast cells. Furthermore, its antioxidant activity protects against oxidative damage and chronic diseases. Finally, zinc improves the ability to trigger effective immune responses against pathogens by contributing to the maturation of lymphocytes, the production of cytokines, and the regulation of apoptosis. Given these properties, zinc can be considered an adjunctive therapy in treating and preventing respiratory, nephrological, and gastrointestinal diseases, both acute and chronic. This review aims to deepen the role and metabolism of zinc, focusing on the role of supplementation in developed countries in pediatric diseases. 000136116 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/ 000136116 590__ $$a4.8$$b2024 000136116 592__ $$a1.333$$b2024 000136116 591__ $$aBIOCHEMISTRY & MOLECULAR BIOLOGY$$b75 / 319 = 0.235$$c2024$$dQ1$$eT1 000136116 593__ $$aBiochemistry$$c2024$$dQ1 000136116 593__ $$aMolecular Biology$$c2024$$dQ2 000136116 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000136116 700__ $$aPiccoli, E. 000136116 700__ $$aPietrobelli, A. 000136116 700__ $$0(orcid)0000-0003-0454-653X$$aMoreno, L. A.$$uUniversidad de Zaragoza 000136116 700__ $$aPiacentini, G. 000136116 700__ $$aPecoraro, L. 000136116 7102_ $$11006$$2255$$aUniversidad de Zaragoza$$bDpto. Fisiatría y Enfermería$$cÁrea Enfermería 000136116 773__ $$g14, 718 (2024), 25$$tBiomolecules$$x2218-273X 000136116 8564_ $$s512695$$uhttps://zaguan.unizar.es/record/136116/files/texto_completo.pdf$$yVersión publicada 000136116 8564_ $$s2706796$$uhttps://zaguan.unizar.es/record/136116/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000136116 909CO $$ooai:zaguan.unizar.es:136116$$particulos$$pdriver 000136116 951__ $$a2025-09-22-14:40:59 000136116 980__ $$aARTICLE
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