136116 20260217205551.0 doi 10.3390/biom14060718 sideral 139052 ART-2024-139052 eng Padoan, F. The role of Zinc in developed countries in pediatric patients: a 360-degree view 2024 Access copy available to the general public Unrestricted Zinc is an important trace element for growth and health at pediatric ages. Zinc is fundamental in inflammatory pathways, oxidative balance, and immune function. Zinc exhibits anti-inflammatory properties by modulating Nuclear Factor-kappa (NF-κB) activity and reducing histamine release from basophils, leukocytes, and mast cells. Furthermore, its antioxidant activity protects against oxidative damage and chronic diseases. Finally, zinc improves the ability to trigger effective immune responses against pathogens by contributing to the maturation of lymphocytes, the production of cytokines, and the regulation of apoptosis. Given these properties, zinc can be considered an adjunctive therapy in treating and preventing respiratory, nephrological, and gastrointestinal diseases, both acute and chronic. This review aims to deepen the role and metabolism of zinc, focusing on the role of supplementation in developed countries in pediatric diseases. info:eu-repo/semantics/openAccess by https://creativecommons.org/licenses/by/4.0/deed.es 4.8 2024 BIOCHEMISTRY & MOLECULAR BIOLOGY 75 / 320 = 0.234 2024 Q1 T1 1.333 2024 Biochemistry 2024 Q1 Molecular Biology 2024 Q2 9.2 2024 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Piccoli, E. Pietrobelli, A. Moreno, L. A. Universidad de Zaragoza (orcid)0000-0003-0454-653X Piacentini, G. Pecoraro, L. 1006 255 Universidad de Zaragoza Dpto. Fisiatría y Enfermería Área Enfermería 14, 718 (2024), 25 Biomolecules 2218-273X 512695 http://zaguan.unizar.es/record/136116/files/texto_completo.pdf Versión publicada 2706796 http://zaguan.unizar.es/record/136116/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:136116 articulos driver 2026-02-17-20:40:23 ARTICLE