000136141 001__ 136141 000136141 005__ 20240719195437.0 000136141 0247_ $$2doi$$a10.1016/j.compbiomed.2024.108831 000136141 0248_ $$2sideral$$a139122 000136141 037__ $$aART-2024-139122 000136141 041__ $$aeng 000136141 100__ $$0(orcid)0000-0002-3784-1140$$aBorau, C. 000136141 245__ $$aAn agent-based model for cell microenvironment simulation using FLAMEGPU2 000136141 260__ $$c2024 000136141 5060_ $$aAccess copy available to the general public$$fUnrestricted 000136141 5203_ $$aThis work presents an advanced agent-based model developed within the FLAMEGPU2 framework, aimed at simulating the intricate dynamics of cell microenvironments. Our primary objective is to showcase FLAMEGPU2's potential in modelling critical features such as cell-cell and cell-ECM interactions, species diffusion, vascularisation, cell migration, and/or cell cycling. By doing so, we provide a versatile template that serves as a foundational platform for researchers to model specific biological mechanisms or processes. We highlight the utility of our approach as a microscale component within multiscale frameworks. Through four example applications, we demonstrate the model's versatility in capturing phenomena such as strain-stiffening behaviour of hydrogels, cell migration patterns within hydrogels, spheroid formation and fibre reorientation, and the simulation of diffusion processes within a vascularised and deformable domain. This work aims to bridge the gap between computational efficiency and biological fidelity, offering a scalable and flexible platform to advance our understanding of tissue biology and engineering. 000136141 536__ $$9info:eu-repo/grantAgreement/EC/H2020/826494/EU/PRedictive In-silico Multiscale Analytics to support cancer personalized diaGnosis and prognosis, Empowered by imaging biomarkers/PRIMAGE$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 826494-PRIMAGE 000136141 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/ 000136141 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000136141 700__ $$aChisholm, R. 000136141 700__ $$aRichmond, P. 000136141 700__ $$aWalker, D. 000136141 773__ $$g179 (2024), 12 pp.$$pComput. biol. med.$$tComputers in biology and medicine$$x0010-4825 000136141 8564_ $$s8610600$$uhttps://zaguan.unizar.es/record/136141/files/texto_completo.pdf$$yVersión publicada 000136141 8564_ $$s2507037$$uhttps://zaguan.unizar.es/record/136141/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000136141 909CO $$ooai:zaguan.unizar.es:136141$$particulos$$pdriver 000136141 951__ $$a2024-07-19-18:28:02 000136141 980__ $$aARTICLE