136141 20260217205517.0 doi 10.1016/j.compbiomed.2024.108831 sideral 139122 ART-2024-139122 eng Borau, C. (orcid)0000-0002-3784-1140 An agent-based model for cell microenvironment simulation using FLAMEGPU2 2024 Access copy available to the general public Unrestricted This work presents an advanced agent-based model developed within the FLAMEGPU2 framework, aimed at simulating the intricate dynamics of cell microenvironments. Our primary objective is to showcase FLAMEGPU2's potential in modelling critical features such as cell-cell and cell-ECM interactions, species diffusion, vascularisation, cell migration, and/or cell cycling. By doing so, we provide a versatile template that serves as a foundational platform for researchers to model specific biological mechanisms or processes. We highlight the utility of our approach as a microscale component within multiscale frameworks. Through four example applications, we demonstrate the model's versatility in capturing phenomena such as strain-stiffening behaviour of hydrogels, cell migration patterns within hydrogels, spheroid formation and fibre reorientation, and the simulation of diffusion processes within a vascularised and deformable domain. This work aims to bridge the gap between computational efficiency and biological fidelity, offering a scalable and flexible platform to advance our understanding of tissue biology and engineering. info:eu-repo/grantAgreement/EC/H2020/826494/EU/PRedictive In-silico Multiscale Analytics to support cancer personalized diaGnosis and prognosis, Empowered by imaging biomarkers/PRIMAGE This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 826494-PRIMAGE info:eu-repo/semantics/openAccess by https://creativecommons.org/licenses/by/4.0/deed.es 6.3 2024 BIOLOGY 7 / 107 = 0.065 2024 Q1 T1 MATHEMATICAL & COMPUTATIONAL BIOLOGY 4 / 67 = 0.06 2024 Q1 T1 ENGINEERING, BIOMEDICAL 22 / 124 = 0.177 2024 Q1 T1 COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS 26 / 177 = 0.147 2024 Q1 T1 1.447 2024 Health Informatics 2024 Q1 Computer Science Applications 2024 Q1 13.0 2024 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Chisholm, R. Richmond, P. Walker, D. 179 (2024), 12 pp. Comput. biol. med. Computers in biology and medicine 0010-4825 8610600 http://zaguan.unizar.es/record/136141/files/texto_completo.pdf Versión publicada 2507037 http://zaguan.unizar.es/record/136141/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:136141 articulos driver 2026-02-17-20:27:29 ARTICLE