000136205 001__ 136205
000136205 005__ 20240719195438.0
000136205 0247_ $$2doi$$a10.1016/j.bbr.2024.115127
000136205 0248_ $$2sideral$$a139087
000136205 037__ $$aART-2024-139087
000136205 041__ $$aeng
000136205 100__ $$aLlana, Tania
000136205 245__ $$aAn immersive virtual reality-based object-location memory task reveals spatial long-term memory alterations in Long-COVID
000136205 260__ $$c2024
000136205 5060_ $$aAccess copy available to the general public$$fUnrestricted
000136205 5203_ $$aObject-location memory (OLM) is a type of declarative memory for spatial information and consists of the individual's ability to establish accurate associations between objects and their spatial locations. Long-COVID describes the long-term effects of the COVID-19 disease. Long-COVID patients show medial temporal lobe dysfunction and neuropsychological alterations affecting memory. This study aimed to assess OLM in a group of Long-COVID patients, n=66, and a Control group of healthy individuals with similar age and sex composition, n=21, using an immersive virtual reality (iVR)-based OLM task. We also explored associations between the performance in the iVR-based OLM task and general cognitive function (MoCA), and both verbal (VSTM) and visuospatial (SSTM) span. The Long-COVID group showed fewer correct responses, made more task attempts, and invested more time in the iVR-based OLM task than the Control group. Delayed memory was more severely altered than immediate memory in Long-COVID participants. Better MoCA scores of the Long-COVID group were strongly associated with shorter times to complete the immediate recall of the iVR-based OLM task. Besides, the months elapsed since the COVID-19 infection were slightly associated with fewer correct responses in the immediate and 24-hour recalls. These results corroborate previous findings of memory alterations in the Long-COVID syndrome using an iVR-based OLM task, adding new evidence on spatial memory and long-term memory in this population. Implementing spatial iVR tasks to clinical research may improve our understanding of neuropsychological disorders.
000136205 536__ $$9info:eu-repo/grantAgreement/ES/DGA/S31-23R$$9info:eu-repo/grantAgreement/ES/NextGenerationEU/INVESTIGO-067-38
000136205 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc$$uhttp://creativecommons.org/licenses/by-nc/3.0/es/
000136205 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000136205 700__ $$0(orcid)0000-0001-6285-8158$$aGarcés-Arilla, Sara$$uUniversidad de Zaragoza
000136205 700__ $$aJuan, M. Carmen
000136205 700__ $$0(orcid)0000-0002-4249-602X$$aMéndez-López, Magdalena$$uUniversidad de Zaragoza
000136205 700__ $$aMéndez, Marta
000136205 7102_ $$14009$$2725$$aUniversidad de Zaragoza$$bDpto. Psicología y Sociología$$cÁrea Psicobiología
000136205 773__ $$g471 (2024), 115127 [12 pp.]$$pBehav. brain res.$$tBehavioural brain research$$x0166-4328
000136205 8564_ $$s2737628$$uhttps://zaguan.unizar.es/record/136205/files/texto_completo.pdf$$yVersión publicada
000136205 8564_ $$s2297843$$uhttps://zaguan.unizar.es/record/136205/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000136205 909CO $$ooai:zaguan.unizar.es:136205$$particulos$$pdriver
000136205 951__ $$a2024-07-19-18:29:17
000136205 980__ $$aARTICLE