136205 20260217205547.0 doi 10.1016/j.bbr.2024.115127 sideral 139087 ART-2024-139087 eng Llana, Tania An immersive virtual reality-based object-location memory task reveals spatial long-term memory alterations in Long-COVID 2024 Access copy available to the general public Unrestricted Object-location memory (OLM) is a type of declarative memory for spatial information and consists of the individual's ability to establish accurate associations between objects and their spatial locations. Long-COVID describes the long-term effects of the COVID-19 disease. Long-COVID patients show medial temporal lobe dysfunction and neuropsychological alterations affecting memory. This study aimed to assess OLM in a group of Long-COVID patients, n=66, and a Control group of healthy individuals with similar age and sex composition, n=21, using an immersive virtual reality (iVR)-based OLM task. We also explored associations between the performance in the iVR-based OLM task and general cognitive function (MoCA), and both verbal (VSTM) and visuospatial (SSTM) span. The Long-COVID group showed fewer correct responses, made more task attempts, and invested more time in the iVR-based OLM task than the Control group. Delayed memory was more severely altered than immediate memory in Long-COVID participants. Better MoCA scores of the Long-COVID group were strongly associated with shorter times to complete the immediate recall of the iVR-based OLM task. Besides, the months elapsed since the COVID-19 infection were slightly associated with fewer correct responses in the immediate and 24-hour recalls. These results corroborate previous findings of memory alterations in the Long-COVID syndrome using an iVR-based OLM task, adding new evidence on spatial memory and long-term memory in this population. Implementing spatial iVR tasks to clinical research may improve our understanding of neuropsychological disorders. info:eu-repo/grantAgreement/ES/DGA/S31-23R info:eu-repo/grantAgreement/ES/NextGenerationEU/INVESTIGO-067-38 info:eu-repo/semantics/openAccess by-nc https://creativecommons.org/licenses/by-nc/4.0/deed.es 2.3 2024 BEHAVIORAL SCIENCES 21 / 57 = 0.368 2024 Q2 T2 NEUROSCIENCES 213 / 314 = 0.678 2024 Q3 T3 0.919 2024 Behavioral Neuroscience 2024 Q2 5.5 2024 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Garcés-Arilla, Sara Universidad de Zaragoza (orcid)0000-0001-6285-8158 Juan, M. Carmen Méndez-López, Magdalena Universidad de Zaragoza (orcid)0000-0002-4249-602X Méndez, Marta 4009 725 Universidad de Zaragoza Dpto. Psicología y Sociología Área Psicobiología 471 (2024), 115127 [12 pp.] Behav. brain res. Behavioural brain research 0166-4328 2737628 http://zaguan.unizar.es/record/136205/files/texto_completo.pdf Versión publicada 2297843 http://zaguan.unizar.es/record/136205/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:136205 articulos driver 2026-02-17-20:38:42 ARTICLE