000136251 001__ 136251
000136251 005__ 20260112133143.0
000136251 0247_ $$2doi$$a10.1002/adfm.202405282
000136251 0248_ $$2sideral$$a139199
000136251 037__ $$aART-2024-139199
000136251 041__ $$aeng
000136251 100__ $$aTommasini, Giuseppina
000136251 245__ $$aRemote magneto–thermal modulation of reactive oxygen species balance enhances tissue regeneration in vivo
000136251 260__ $$c2024
000136251 5060_ $$aAccess copy available to the general public$$fUnrestricted
000136251 5203_ $$aOne of the hallmarks of tissue repair is the production of reactive oxygen species (ROS), which modulate processes such as cell proliferation. Although several attempts have been made to manipulate ROS levels to increase tissue repair, the lack of techniques able to remotely manipulate the redox homeostasis with spatio–temporal fashion has hindered its progress. Herein, a new approach for tuning the ROS levels using magnetic nanoparticles (MNPs) that act as nanoheaters when exposed to an alternating magnetic field is presented. Two manganese–iron oxide (MnxFe3−xO4) MNPs (with a low and a high Mn2+ content) are designed and probed for the possibility of modulating the ROS balance by magneto–thermal stimulation in the invertebrate model organism Hydra vulgaris, able to fully regenerate. By evaluating the expression of selected genes involved in the maintenance of ROS homeostasis and proliferation pathways, a biphasic modulation of the ROS levels played by the MNPs is found. While MNPs with a lower Mn2+ content are able to positively modulate the regeneration potential under magnetostimulation, MNPs with a higher Mn2+ content cause a different redox imbalance, negatively affecting the regeneration dynamic. This innovative approach reveals a novel way of manipulating redox homeostasis that can advance in the field of tissue engineering.
000136251 536__ $$9info:eu-repo/grantAgreement/ES/DGA/E15-23R$$9info:eu-repo/grantAgreement/EC/HORIZON EUROPE/101064735/EU/Tunning the force for remote magnetomechanical gating of Piezo1 channels/MAGPIEZ$$9info:eu-repo/grantAgreement/EC/H2020/853468/EU/Remote control of cellular signalling triggered by magnetic switching/SIROCCO$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 853468-SIROCCO$$9info:eu-repo/grantAgreement/ES/MICINN/CNS2022-135700
000136251 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc$$uhttps://creativecommons.org/licenses/by-nc/4.0/deed.es
000136251 590__ $$a19.0$$b2024
000136251 592__ $$a5.439$$b2024
000136251 591__ $$aCHEMISTRY, PHYSICAL$$b12 / 185 = 0.065$$c2024$$dQ1$$eT1
000136251 591__ $$aMATERIALS SCIENCE, MULTIDISCIPLINARY$$b23 / 460 = 0.05$$c2024$$dQ1$$eT1
000136251 591__ $$aNANOSCIENCE & NANOTECHNOLOGY$$b9 / 147 = 0.061$$c2024$$dQ1$$eT1
000136251 591__ $$aPHYSICS, CONDENSED MATTER$$b5 / 79 = 0.063$$c2024$$dQ1$$eT1
000136251 591__ $$aCHEMISTRY, MULTIDISCIPLINARY$$b13 / 239 = 0.054$$c2024$$dQ1$$eT1
000136251 591__ $$aPHYSICS, APPLIED$$b9 / 187 = 0.048$$c2024$$dQ1$$eT1
000136251 593__ $$aBiomaterials$$c2024$$dQ1
000136251 593__ $$aChemistry (miscellaneous)$$c2024$$dQ1
000136251 593__ $$aCondensed Matter Physics$$c2024$$dQ1
000136251 593__ $$aNanoscience and Nanotechnology$$c2024$$dQ1
000136251 593__ $$aElectronic, Optical and Magnetic Materials$$c2024$$dQ1
000136251 593__ $$aMaterials Science (miscellaneous)$$c2024$$dQ1
000136251 593__ $$aElectrochemistry$$c2024$$dQ1
000136251 594__ $$a27.7$$b2024
000136251 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000136251 700__ $$aSol-Fernández, Susel Del
000136251 700__ $$aFlavián-Lázaro, Ana Cristina
000136251 700__ $$aLewinska, Anna
000136251 700__ $$aWnuk, Maciej
000136251 700__ $$aTortiglione, Claudia
000136251 700__ $$0(orcid)0000-0002-2861-2469$$aMoros, María
000136251 773__ $$g34, 39 (2024), 2405282 [16 pp.]$$pAdv. funct. mater.$$tAdvanced Functional Materials$$x1616-301X
000136251 8564_ $$s8405935$$uhttps://zaguan.unizar.es/record/136251/files/texto_completo.pdf$$yVersión publicada
000136251 8564_ $$s3010407$$uhttps://zaguan.unizar.es/record/136251/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000136251 909CO $$ooai:zaguan.unizar.es:136251$$particulos$$pdriver
000136251 951__ $$a2026-01-12-12:36:06
000136251 980__ $$aARTICLE