000136280 001__ 136280
000136280 005__ 20240731105611.0
000136280 0247_ $$2doi$$a10.3390/jcm13133885
000136280 0248_ $$2sideral$$a139263
000136280 037__ $$aART-2024-139263
000136280 041__ $$aeng
000136280 100__ $$aPérez, Marina
000136280 245__ $$aMicrobiota-derived short-chain fatty acids boost antitumoral natural killer cell activity
000136280 260__ $$c2024
000136280 5060_ $$aAccess copy available to the general public$$fUnrestricted
000136280 5203_ $$aBackground: The intestinal microbiota can regulate numerous host functions, including the immune response. Through fermentation, the microbiota produces and releases microbial metabolites such as short-chain fatty acids (SCFAs), which can affect host homeostasis. There is growing evidence that the gut microbiome can have a major impact on cancer. Specific gut microbial composition and metabolites are associated with tumor status in the host. However, their effects on the antitumor response have scarcely been investigated. Natural killer (NK) cells play an important role in antitumor immunity due to their ability to directly identify and eliminate tumor cells. Methods: The aim of this study was to investigate the effects of SCFAs on antitumoral NK cell activity, using NK-92 cell line. Results: Here, we describe how SCFAs can boost antitumoral NK cell activity. The SCFAs induced the release of NK extracellular vesicles and reduced the secretion of the anti-inflammatory cytokine IL-10. The SCFAs also increased the cytotoxicity of the NK cells against multiple myeloma cells. Conclusions: Our results indicate, for the first time, the enormous potential of SCFAs in regulating antitumoral NK cell defense, where modulation of the SCFAs’ production could play a fundamental role in cancer immunotherapy.
000136280 536__ $$9info:eu-repo/grantAgreement/ES/DGA/B23-20R$$9info:eu-repo/grantAgreement/ES/UZ/JIUZ-2021-BIO-02
000136280 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000136280 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000136280 700__ $$0(orcid)0000-0002-8467-0356$$aBuey, Berta$$uUniversidad de Zaragoza
000136280 700__ $$aCorral, Pilar$$uUniversidad de Zaragoza
000136280 700__ $$aGiraldos, David
000136280 700__ $$0(orcid)0000-0002-5797-3909$$aLatorre, Eva$$uUniversidad de Zaragoza
000136280 7102_ $$11012$$2410$$aUniversidad de Zaragoza$$bDpto. Farmac.Fisiol.y Med.L.F.$$cÁrea Fisiología
000136280 7102_ $$11002$$2050$$aUniversidad de Zaragoza$$bDpto. Bioq.Biolog.Mol. Celular$$cÁrea Biología Celular
000136280 773__ $$g13, 13 (2024), 3885 [12 pp.]$$pJ. clin.med.$$tJournal of Clinical Medicine$$x2077-0383
000136280 8564_ $$s1157572$$uhttps://zaguan.unizar.es/record/136280/files/texto_completo.pdf$$yVersión publicada
000136280 8564_ $$s2614089$$uhttps://zaguan.unizar.es/record/136280/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000136280 909CO $$ooai:zaguan.unizar.es:136280$$particulos$$pdriver
000136280 951__ $$a2024-07-31-09:22:07
000136280 980__ $$aARTICLE