136280 20260217205522.0 doi 10.3390/jcm13133885 sideral 139263 ART-2024-139263 eng Pérez, Marina Microbiota-derived short-chain fatty acids boost antitumoral natural killer cell activity 2024 Access copy available to the general public Unrestricted Background: The intestinal microbiota can regulate numerous host functions, including the immune response. Through fermentation, the microbiota produces and releases microbial metabolites such as short-chain fatty acids (SCFAs), which can affect host homeostasis. There is growing evidence that the gut microbiome can have a major impact on cancer. Specific gut microbial composition and metabolites are associated with tumor status in the host. However, their effects on the antitumor response have scarcely been investigated. Natural killer (NK) cells play an important role in antitumor immunity due to their ability to directly identify and eliminate tumor cells. Methods: The aim of this study was to investigate the effects of SCFAs on antitumoral NK cell activity, using NK-92 cell line. Results: Here, we describe how SCFAs can boost antitumoral NK cell activity. The SCFAs induced the release of NK extracellular vesicles and reduced the secretion of the anti-inflammatory cytokine IL-10. The SCFAs also increased the cytotoxicity of the NK cells against multiple myeloma cells. Conclusions: Our results indicate, for the first time, the enormous potential of SCFAs in regulating antitumoral NK cell defense, where modulation of the SCFAs’ production could play a fundamental role in cancer immunotherapy. info:eu-repo/grantAgreement/ES/DGA/B23-20R info:eu-repo/grantAgreement/ES/UZ/JIUZ-2021-BIO-02 info:eu-repo/semantics/openAccess by https://creativecommons.org/licenses/by/4.0/deed.es 2.9 2024 MEDICINE, GENERAL & INTERNAL 65 / 332 = 0.196 2024 Q1 T1 0.919 2024 Medicine (miscellaneous) 2024 Q1 5.2 2024 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Buey, Berta Universidad de Zaragoza (orcid)0000-0002-8467-0356 Corral, Pilar Universidad de Zaragoza Giraldos, David Latorre, Eva Universidad de Zaragoza (orcid)0000-0002-5797-3909 1001 025 Universidad de Zaragoza Dpto. Anatom.,Embri.Genét.Ani. Área Anatom.Anatom.Patológ.Com 1002 050 Universidad de Zaragoza Dpto. Bioq.Biolog.Mol. Celular Área Biología Celular 13, 13 (2024), 3885 [12 pp.] J. clin.med. Journal of Clinical Medicine 2077-0383 1157572 http://zaguan.unizar.es/record/136280/files/texto_completo.pdf Versión publicada 2614089 http://zaguan.unizar.es/record/136280/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:136280 articulos driver 2026-02-17-20:29:08 ARTICLE