doi:10.1007/s00436-024-08282-2engde la Fuente, JoséEstrada-Peña, AgustínLabruna, Marcelo B.Szabó, Matias P. J.Interaction between spiders and ticks—ancient arthropod predatory behavior?ART-2024-139258Ticks are ectoparasite vectors of pathogens affecting human and animal health worldwide. Rational integration of different control interventions including plant-derived repellents and acaricides, management of natural predators, and vaccines is required for innovative approaches to reduce the risks associated with ticks and tick-borne diseases. How tick populations are naturally controlled is always a question. Tick interactions with other arthropods including predators evolved from ancient times. In this study, Cretaceous (ca. 100 Mya) Burmese amber inclusions were identified as probably related to Compluriscutula vetulum (Acari: Ixodida: Ixodidae) tick larvae and spider silk. As illustrated in this study, ancient interactions between ticks and spiders may support arthropod predatory behavior as a natural control intervention. Rational integrative management of different tick control interventions including natural predators under a One Health perspective will contribute to effectively and sustainably reducing the risks associated with ticks and tick-borne diseases.2024http://zaguan.unizar.es/record/13628110.1007/s00436-024-08282-2http://zaguan.unizar.es/record/136281oai:zaguan.unizar.es:136281Parasitology Research 123, 7 (2024), 264 [4 pp.]byhttps://creativecommons.org/licenses/by/4.0/deed.esinfo:eu-repo/semantics/openAccess