136301 20260218132342.0 doi 10.1016/j.heliyon.2024.e33684 sideral 139276 ART-2024-139276 eng Zapata-García, María Impact of antibiotics, corticosteroids, and microbiota on immunotherapy efficacy in patients with non-small cell lung cancer 2024 Access copy available to the general public Unrestricted Lung cancer is a leading cause of morbidity and mortality globally, with its high mortality rate attributed mainly to non-small cell lung cancer (NSCLC). Although immunotherapy with immune checkpoint inhibitors (ICI) has revolutionized its treatment, patient response is highly variable and lacking predictive markers. We conducted a prospective study on 55 patients with NSCLC undergoing ICI therapy to identify predictive markers of both response and immune-related adverse events (IrAEs) in the airway microbiota. We also analyzed the clinical evolution and overall survival (OS) with respect to treatments that affect the integrity of the microbiota, such as antibiotics and corticosteroids. Our results demonstrated that respiratory microbiota differ significantly in ICI responders: they have higher alpha diversity values and lower abundance of the Firmicutes phylum and the Streptococcus genus. Employing a logistic regression model, the abundance of Gemella was the major predictor of non-ICI response, whereas Lachnoanaerobaculum was the best predictor of a positive response to ICI. The most relevant results were that antibiotic consumption is linked to a lower ICI response, and the use of corticosteroids correlated with poorer overall survival. Whereas previous studies have focused on gut microbiota, our findings highlight the importance of the respiratory microbiota in predicting the treatment response. Future research should explore microbiota modulation strategies to enhance immunotherapy outcomes. Understanding the impact of antibiotics, corticosteroids, and microbiota on NSCLC immunotherapy will help personalize treatment and improve patient outcomes info:eu-repo/semantics/openAccess by-nc https://creativecommons.org/licenses/by-nc/4.0/deed.es 3.6 2024 MULTIDISCIPLINARY SCIENCES 29 / 136 = 0.213 2024 Q1 T1 0.644 2024 Multidisciplinary 2024 Q1 4.1 2024 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Moratiel-Pellitero, Alba Isla, Dolores Gálvez, Eva Universidad de Zaragoza Gascón-Ruiz, Marta Universidad de Zaragoza (orcid)0000-0002-6811-6654 Sesma, Andrea (orcid)0000-0002-3888-7036 Barbero, Raquel Galeano, Javier Campo, Rosa del Ocáriz, Maitane Quílez, Elisa Cruellas, Mara Ramírez Labrada, Ariel Pardo, Julián Universidad de Zaragoza (orcid)0000-0003-0154-0730 Martínez Lostao, Luis Universidad de Zaragoza (orcid)0000-0003-3043-147X Domingo, María Pilar Esteban, Patricia Torres-Ramón, Irene (orcid)0000-0003-3387-0558 Yubero, Alfonso Paño, José Ramón Universidad de Zaragoza (orcid)0000-0002-9600-8116 Lastra, Rodrigo 1006 255 Universidad de Zaragoza Dpto. Fisiatría y Enfermería Área Enfermería 1007 610 Universidad de Zaragoza Dpto. Medicina, Psiqu. y Derm. Area Medicina 1011 566 Universidad de Zaragoza Dpto. Microb.Ped.Radio.Sal.Pú. Área Inmunología 10, 13 (2024), e33684 [13 pp.] Heliyon Heliyon 2405-8440 4955506 http://zaguan.unizar.es/record/136301/files/texto_completo.pdf Versión publicada 1850174 http://zaguan.unizar.es/record/136301/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:136301 articulos driver 2026-02-18-12:27:27 ARTICLE