000136332 001__ 136332 000136332 005__ 20250923084426.0 000136332 0247_ $$2doi$$a10.1093/ecco-jcc/jjad184 000136332 0248_ $$2sideral$$a139315 000136332 037__ $$aART-2024-139315 000136332 041__ $$aeng 000136332 100__ $$0(orcid)0000-0001-6883-8940$$aCasas Deza, Diego$$uUniversidad de Zaragoza 000136332 245__ $$aInitial Management of Intra-abdominal Abscesses and Preventive Strategies for Abscess Recurrence in Penetrating Crohn’s Disease: A National, Multicentre Study Based on ENEIDA Registry 000136332 260__ $$c2024 000136332 5203_ $$aIntroduction Intra-abdominal abscesses complicating Crohn’s disease [CD] are a challenging situation. Their management, during hospitalisation and after resolution, is still unclear. Methods Adult patients with CD complicated with intra-abdominal abscess. who required hospitalisation, were included from the prospectively maintained ENEIDA registry from GETECCU. Initial strategy effectiveness and safety to resolve abscess was assessed. Survival analysis was performed to evaluate recurrence risk. Predictive factors associated with resolution were evaluated by multivariate regression and predictive factors associated with recurrence were assessed by Cox regression. Results In all, 520 patients from 37 Spanish hospitals were included; 322 [63%] were initially treated with antibiotics alone, 128 [26%] with percutaneous drainage, and 54 [17%] with surgical drainage. The size of the abscess was critical to the effectiveness of each treatment. In abscesses < 30 mm, the antibiotic was as effective as percutaneous or surgical drainage. However, in larger abscesses, percutaneous or surgical drainage was superior. In abscesses > 50 mm, surgery was superior to percutaneous drainage, although it was associated with a higher complication rate. After abscess resolution, luminal resection was associated with a lower 1-year abscess recurrence risk [HR 0.43, 95% CI 0.24-0.76]. However, those patients who initiated anti-TNF therapy had a similar recurrence risk whether luminal resection had been performed. Conclusions Small abscesses [<30mm] can be managed with antibiotics alone; larger ones require drainage. Percutaneous drainage will be effective and safer than surgery in many cases. After discharge, anti-TNF therapy reduces abscess recurrence risk in a similar way to bowel resection. 000136332 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII-FEDER/CM21-00067 000136332 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/ 000136332 590__ $$a8.7$$b2024 000136332 592__ $$a2.991$$b2024 000136332 591__ $$aGASTROENTEROLOGY & HEPATOLOGY$$b12 / 147 = 0.082$$c2024$$dQ1$$eT1 000136332 593__ $$aMedicine (miscellaneous)$$c2024$$dQ1 000136332 593__ $$aGastroenterology$$c2024$$dQ1 000136332 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000136332 700__ $$aPolo Cuadro, Cristina 000136332 700__ $$ade Francisco, Ruth 000136332 700__ $$aVela González, Milagros 000136332 700__ $$aBermejo, Fernando 000136332 700__ $$aBlanco, Ignacio 000136332 700__ $$ade la Serna, Álvaro 000136332 700__ $$aBujanda, Luis 000136332 700__ $$aBernal, Lorena 000136332 700__ $$aRueda García, José Luis 000136332 700__ $$0(orcid)0000-0002-3545-2707$$aGargallo-Puyuelo, Carla J$$uUniversidad de Zaragoza 000136332 700__ $$aFuentes-Valenzuela, Esteban 000136332 700__ $$aCastro, Beatriz 000136332 700__ $$aGuardiola, Jordi 000136332 700__ $$aLadrón, Gemma 000136332 700__ $$aSuria, Carles 000136332 700__ $$aSáez Fuster, Julia 000136332 700__ $$aGisbert, Javier P 000136332 700__ $$aSicilia, Beatriz 000136332 700__ $$aGomez, Raquel 000136332 700__ $$aMuñoz Vilafranca, Carmen 000136332 700__ $$aBarreiro-De Acosta, Manuel 000136332 700__ $$aPeña, Elena 000136332 700__ $$aCastillo Pradillo, Marta 000136332 700__ $$aCerrillo, Elena 000136332 700__ $$aCalvet, Xavier 000136332 700__ $$aManceñido, Noemí 000136332 700__ $$aMonfort i Miquel, David 000136332 700__ $$aMarín, Sandra 000136332 700__ $$aRoig, Cristina 000136332 700__ $$aMarce, Ainhoa 000136332 700__ $$aRamírez de Piscina, Patricia 000136332 700__ $$aBetoré, Elena 000136332 700__ $$aMartin-Cardona, Albert 000136332 700__ $$aTeller, Marta 000136332 700__ $$aAlonso Abreu, Inmaculada 000136332 700__ $$aMaroto, Nuria 000136332 700__ $$aFrago, Santiago 000136332 700__ $$aGardeazabal, Diego 000136332 700__ $$aPérez-Martínez, Isabel 000136332 700__ $$aFebles González, Ángel David 000136332 700__ $$aBarrero, Sara 000136332 700__ $$aTaxonera, Carlos 000136332 700__ $$aGarcía de la Filia, Irene 000136332 700__ $$aEzkurra-Altuna, Ander 000136332 700__ $$aMadero, Lucía 000136332 700__ $$aMartín-Arranz, María Dolores 000136332 700__ $$0(orcid)0000-0003-0076-3529$$aGomollón, Fernando$$uUniversidad de Zaragoza 000136332 700__ $$aDomènech, Eugeni 000136332 700__ $$0(orcid)0000-0003-3970-5457$$aGarcía-López, Santiago$$uUniversidad de Zaragoza 000136332 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina 000136332 773__ $$g18, 4 (2024), 578-588$$pJ. Crohns Colitis$$tJournal of Crohn's & colitis$$x1873-9946 000136332 8564_ $$s366975$$uhttps://zaguan.unizar.es/record/136332/files/texto_completo.pdf$$yVersión publicada 000136332 8564_ $$s2816875$$uhttps://zaguan.unizar.es/record/136332/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000136332 909CO $$ooai:zaguan.unizar.es:136332$$particulos$$pdriver 000136332 951__ $$a2025-09-22-14:39:52 000136332 980__ $$aARTICLE