Genetic factors and Waldenström's macroglobulinemia: Systematic review and meta-analysis

Santos-Lozano, Alejandro ; Rueda-González, Jesús ; Martín-Hernández, Juan ; Serna-Molpereces, Jorge ; Cristi-Montero, Carlos ; Fiuza-Luces, Carmen ; Baladrón, Carlos ; Pinto-Fraga, José ; Garatachea, Nuria (Universidad de Zaragoza) ; Cedena, María Teresa ; Martínez-López, Joaquín ; Lucia, Alejandro

Resumen: Waldenström's macroglobulinemia (WM) is categorized as a B-cell neoplasia characterized by lymphoplasmacytic infiltration in the bone marrow and the overproduction of serum monoclonal IgM. The precise cause of WM is unknown, but familial patterns suggest the possibility of an underlying genetic defect. The purpose of this study was to determine the association between different gene variations and the development of WM. We studied different genetic variations reporting significant incidence rates. The most representative of those were the MYD88 (L256P) mutation with an incidence rate of 81% and 6q deletion with an incidence rate of 36%. In addition, CXCR4 mutation, 13q14 deletion and trisomy 4 showed an incidence rate of 29%, 12% and 14%, respectively. Finally, the deletion 17p13 was present in 8% of subjects. Our results suggest that the MYD88 (L256P) mutation might be a target for the development of specific therapeutic strategies.

Idioma: Inglés

DOI: 10.15761/HMO.1000173

Año: 2019

Publicado en: Hematology & Medical Oncology 4, 1 (2019), [7 pp.]
ISSN: 2398-8495

Financiación: info:eu-repo/grantAgreement/ES/FIS/PI15-00558

Tipo y forma: Artículo (Versión definitiva)

Área (Departamento): Área Educación Física y Depor. (Dpto. Fisiatría y Enfermería)