000136429 001__ 136429
000136429 005__ 20240826132401.0
000136429 0247_ $$2doi$$a10.1016/j.jhazmat.2024.135202
000136429 0248_ $$2sideral$$a139317
000136429 037__ $$aART-2024-139317
000136429 041__ $$aeng
000136429 100__ $$aRupérez, David$$uUniversidad de Zaragoza
000136429 245__ $$aSynthesis and quantification of oligoesters migrating from starch-based food packaging materials
000136429 260__ $$c2024
000136429 5060_ $$aAccess copy available to the general public$$fUnrestricted
000136429 5203_ $$aThe term oligomer refers to structurally diverse compounds coming from incomplete polymerisation or polymer degradation. Their ability to migrate into foodstuffs along with recent studies about their bioavailability and toxicity have risen concerns about the scarcity of standards needed to perform thorough analytical and toxicological studies. In this work, migration extracts of three starch-based biopolymers films for the packaging of fruits and vegetables were analysed according to European legislation 10/2011. Oligoesters analysed by UPLC-MS(QTOF) were the main non-intentionally added substances (NIAS) identified in the food simulants. A stepwise synthesis approach was used to synthesise and isolate eleven cyclic and linear oligoester standards ranging from 2 to 8 monomers based on adipic acid, 1,4-butanediol, isophtalic acid and propylene glycol monomers. These standards were characterised by 1H and 13C NMR as well as high resolution mass spectrometry. An overall high purity of > 98 % was achieved as detected by UPLC-MS(Orbitrap). The standards were then used to unequivocally identify the oligoesters in the migration assay samples by comparing their UPLC-MS/MS spectra, and to semi-quantify or fully quantify these migrant oligoesters. The oligoester quantification results deemed safe only one out of the three biopolymer films according to their threshold of toxicological concern concept. The work herein described aims to contribute towards the oligomers knowledge gaps, opening the door for comprehensive toxicological risk and absorption, distribution, metabolism, excretion and toxicity (ADMET) studies.
000136429 536__ $$9info:eu-repo/grantAgreement/ES/DGA/T53-23R$$9info:eu-repo/grantAgreement/ES/MICINN/PID2021-128089OB-I00$$9info:eu-repo/grantAgreement/ES/MICINN/RTI2018-097805-B-I00
000136429 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000136429 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000136429 700__ $$aRivière, Matthieu
000136429 700__ $$aLebreton, Jacques
000136429 700__ $$0(orcid)0000-0002-0759-9170$$aAznar, Margarita$$uUniversidad de Zaragoza
000136429 700__ $$0(orcid)0000-0001-7143-8905$$aAlmeida e Silva, Filomena
000136429 700__ $$aTessier, Arnaud
000136429 700__ $$aCariou, Ronan
000136429 700__ $$0(orcid)0000-0003-2685-5739$$aNerín, Cristina$$uUniversidad de Zaragoza
000136429 7102_ $$12009$$2750$$aUniversidad de Zaragoza$$bDpto. Química Analítica$$cÁrea Química Analítica
000136429 773__ $$g476 (2024), 135202 [10 pp.]$$pJ. hazard. mater.$$tJournal of Hazardous Materials$$x0304-3894
000136429 8564_ $$s1504087$$uhttps://zaguan.unizar.es/record/136429/files/texto_completo.pdf$$yVersión publicada
000136429 8564_ $$s1780096$$uhttps://zaguan.unizar.es/record/136429/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000136429 909CO $$ooai:zaguan.unizar.es:136429$$particulos$$pdriver
000136429 951__ $$a2024-08-22-13:17:54
000136429 980__ $$aARTICLE