000136431 001__ 136431
000136431 005__ 20240826132401.0
000136431 0247_ $$2doi$$a10.1080/13854046.2024.2375605
000136431 0248_ $$2sideral$$a139234
000136431 037__ $$aART-2024-139234
000136431 041__ $$aeng
000136431 100__ $$aCano-López, Irene
000136431 245__ $$aCognitive phenotypes in patients with drug-resistant temporal lobe epilepsy: Relationships with cortisol and affectivity
000136431 260__ $$c2024
000136431 5060_ $$aAccess copy available to the general public$$fUnrestricted
000136431 5203_ $$aObjective: Drug-resistant temporal lobe epilepsy (TLE) is a neurological disorder characterized by cognitive deficits. This study examined whether patients with TLE and different cognitive phenotypes differ in cortisol levels and affectivity while controlling for demographic and clinical variables. Methods: In this cross-sectional study, 79 adults with TLE underwent neuropsychological evaluation in which memory, language, attention/processing speed, executive function, and affectivity were assessed. Six saliva samples were collected in the afternoon to examine the ability of the hypothalamic-pituitary-adrenal (HPA) axis to descend according to the circadian rhythm (C1 to C6). The cortisol area under the curve concerning ground (AUCg) was computed to examine global cortisol secretion. Results: Three cognitive phenotypes were identified: memory impairment, generalized impairment, and no impairment. The memory-impairment phenotype showed higher cortisol levels at C4, C5, and C6 than the other groups (p = 0.03, η2 = 0.06), higher cortisol AUCg than the generalized-impairment phenotype (p = 0.004, η2 = 0.14), and a significant reduction in positive affectivity after the evaluation (p = 0.026, η2 = 0.11). Higher cortisol AUCg and reductions in positive affectivity were significant predictors of the memory-impairment phenotype (p < 0.001; Cox and Snell R2 = 0.47). Conclusions: Patients with memory impairment had a slower decline in cortisol levels in the afternoon, which could be interpreted as an inability of the HPA axis to inhibit itself. Thus, chronic stress may influence hippocampus-dependent cognitive function more than other cognitive functions in patients with TLE.
000136431 536__ $$9info:eu-repo/grantAgreement/ES/MICINN/PID2020-118992RB-I00
000136431 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000136431 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000136431 700__ $$aCatalán-Aguilar, Judit
000136431 700__ $$aLozano-García, Alejandro
000136431 700__ $$0(orcid)0000-0003-3920-1099$$aHidalgo, Vanesa$$uUniversidad de Zaragoza
000136431 700__ $$aHampel, Kevin G.
000136431 700__ $$aTormos-Pons, Paula
000136431 700__ $$aSalvador, Alicia
000136431 700__ $$aVillanueva, Vicente
000136431 700__ $$aGonzález-Bono, Esperanza
000136431 7102_ $$14009$$2725$$aUniversidad de Zaragoza$$bDpto. Psicología y Sociología$$cÁrea Psicobiología
000136431 773__ $$g(2024), [24 pp.]$$pNeuropsychol. dev. cogn., Sect. D, Clin. neuropsychol.$$tCLINICAL NEUROPSYCHOLOGIST$$x1385-4046
000136431 8564_ $$s1737725$$uhttps://zaguan.unizar.es/record/136431/files/texto_completo.pdf$$yPostprint$$zinfo:eu-repo/date/embargoEnd/2025-07-04
000136431 8564_ $$s1209583$$uhttps://zaguan.unizar.es/record/136431/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint$$zinfo:eu-repo/date/embargoEnd/2025-07-04
000136431 909CO $$ooai:zaguan.unizar.es:136431$$particulos$$pdriver
000136431 951__ $$a2024-08-22-13:17:56
000136431 980__ $$aARTICLE