136431 20260218073607.0 doi 10.1080/13854046.2024.2375605 sideral 139234 ART-2024-139234 eng Cano-López, Irene Cognitive phenotypes in patients with drug-resistant temporal lobe epilepsy: Relationships with cortisol and affectivity 2024 Access copy available to the general public Unrestricted Objective: Drug-resistant temporal lobe epilepsy (TLE) is a neurological disorder characterized by cognitive deficits. This study examined whether patients with TLE and different cognitive phenotypes differ in cortisol levels and affectivity while controlling for demographic and clinical variables. Methods: In this cross-sectional study, 79 adults with TLE underwent neuropsychological evaluation in which memory, language, attention/processing speed, executive function, and affectivity were assessed. Six saliva samples were collected in the afternoon to examine the ability of the hypothalamic-pituitary-adrenal (HPA) axis to descend according to the circadian rhythm (C1 to C6). The cortisol area under the curve concerning ground (AUCg) was computed to examine global cortisol secretion. Results: Three cognitive phenotypes were identified: memory impairment, generalized impairment, and no impairment. The memory-impairment phenotype showed higher cortisol levels at C4, C5, and C6 than the other groups (p = 0.03, η2 = 0.06), higher cortisol AUCg than the generalized-impairment phenotype (p = 0.004, η2 = 0.14), and a significant reduction in positive affectivity after the evaluation (p = 0.026, η2 = 0.11). Higher cortisol AUCg and reductions in positive affectivity were significant predictors of the memory-impairment phenotype (p < 0.001; Cox and Snell R2 = 0.47). Conclusions: Patients with memory impairment had a slower decline in cortisol levels in the afternoon, which could be interpreted as an inability of the HPA axis to inhibit itself. Thus, chronic stress may influence hippocampus-dependent cognitive function more than other cognitive functions in patients with TLE. info:eu-repo/grantAgreement/ES/MICINN/PID2020-118992RB-I00 info:eu-repo/semantics/openAccess by-nc-nd https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es 2.7 2024 CLINICAL NEUROLOGY 129 / 286 = 0.451 2024 Q2 T2 PSYCHOLOGY, CLINICAL 50 / 185 = 0.27 2024 Q2 T1 PSYCHOLOGY 29 / 93 = 0.312 2024 Q2 T1 0.968 2024 Neuropsychology and Physiological Psychology 2024 Q1 Medicine (miscellaneous) 2024 Q1 Arts and Humanities (miscellaneous) 2024 Q1 Psychiatry and Mental Health 2024 Q2 Clinical Psychology 2024 Q2 Developmental and Educational Psychology 2024 Q2 7.4 2024 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Catalán-Aguilar, Judit Lozano-García, Alejandro (orcid)0000-0003-3920-1099 Hidalgo, Vanesa Universidad de Zaragoza Hampel, Kevin G. Tormos-Pons, Paula Salvador, Alicia Villanueva, Vicente González-Bono, Esperanza 4009 725 Universidad de Zaragoza Dpto. Psicología y Sociología Área Psicobiología 39, 2 (2024), 400-423 Neuropsychol. dev. cogn., Sect. D, Clin. neuropsychol. Neuropsychology, development, and cognition. Section D, The clinical neuropsychologist 1385-4046 1737725 http://zaguan.unizar.es/record/136431/files/texto_completo.pdf Postprint info:eu-repo/date/embargoEnd/2025-07-04 1209583 http://zaguan.unizar.es/record/136431/files/texto_completo.jpg?subformat=icon icon Postprint info:eu-repo/date/embargoEnd/2025-07-04 oai:zaguan.unizar.es:136431 articulos driver 2026-02-17-20:37:06 ARTICLE