000136446 001__ 136446
000136446 005__ 20241220120717.0
000136446 0247_ $$2doi$$a10.1016/j.dld.2024.05.021
000136446 0248_ $$2sideral$$a139335
000136446 037__ $$aART-2024-139335
000136446 041__ $$aeng
000136446 100__ $$aSanz Segura, Patricia$$uUniversidad de Zaragoza
000136446 245__ $$aPsoriasis induced by antiTNF therapy in inflammatory bowel disease: Therapeutic management and evolution of both diseases in a nationwide cohort study
000136446 260__ $$c2024
000136446 5060_ $$aAccess copy available to the general public$$fUnrestricted
000136446 5203_ $$aBackground
some patients with inflammatory bowel disease (IBD) treated with antiTNF develop drug-induced psoriasis (antiTNF-IP). Several therapeutic strategies are possible.
Aims
to assess the management of antiTNF-IP in IBD, and its impact in both diseases.
Methods
patients with antiTNF-IP from ENEIDA registry were included. Therapeutic strategy was classified as continuing the same antiTNF, stopping antiTNF, switch to another antiTNF or swap to a non-antiTNF biologic. IP severity and IBD activity were assessed at baseline and 16, 32 and 54 weeks.
Results
234 patients were included. At baseline, antiTNF-IP was moderate-severe in 60 % of them, and IBD was in remission in 80 %. Therapeutic strategy was associated to antiTNF-IP severity (p < 0.001). AntiTNF-IP improved at week 54 with all strategies, but continuing with the same antiTNF showed the worst results (p = 0.042). Among patients with IBD in remission, relapse was higher in those who stopped antiTNF (p = 0.025). In multivariate analysis, stopping antiTNF, trunk and palms and soles location were associated with antiTNF-IP remission; female sex and previous surgery in Crohn´s disease with IBD relapse.
Conclusion
skin lesions severity and IBD activity seem to determine antiTNF-IP management. Continuing antiTNF in mild antiTNF-IP, and swap to ustekinumab or switch to another antiTNF in moderate-severe cases, are suitable strategies.
000136446 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000136446 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000136446 700__ $$0(orcid)0000-0003-0076-3529$$aGomollón, Fernando$$uUniversidad de Zaragoza
000136446 700__ $$0(orcid)0000-0001-6883-8940$$aCasas, Diego$$uUniversidad de Zaragoza
000136446 700__ $$aIborra, Marisa
000136446 700__ $$aVela, Milagros
000136446 700__ $$aFernández-Clotet, Agnès
000136446 700__ $$aMuñoz, Roser
000136446 700__ $$aGarcía de la Filia, Irene
000136446 700__ $$aGarcía Prada, María
000136446 700__ $$aFerrer Rosique, Juan Ángel
000136446 700__ $$aGarcía, María José
000136446 700__ $$ade Francisco, Ruth
000136446 700__ $$aArias, Lara
000136446 700__ $$aBarrio, Jesús
000136446 700__ $$aGuerra, Iván
000136446 700__ $$aPonferrada, Ángel
000136446 700__ $$aGisbert, Javier P.
000136446 700__ $$aCarrillo-Palau, Marta
000136446 700__ $$aCalvet, Xavier
000136446 700__ $$aMárquez-Mosquera, Lucía
000136446 700__ $$aGros, Beatriz
000136446 700__ $$aCañete, Fiorella
000136446 700__ $$aMonfort, David
000136446 700__ $$aMadrigal Domínguez, Rosa Eva
000136446 700__ $$aRoncero, Óscar
000136446 700__ $$aLaredo, Viviana
000136446 700__ $$0(orcid)0000-0001-7676-9842$$aMontoro, Miguel$$uUniversidad de Zaragoza
000136446 700__ $$aMuñoz, Carmen
000136446 700__ $$aLópez-Cauce, Beatriz
000136446 700__ $$aLorente, Rufo
000136446 700__ $$aFuentes Coronel, Ana
000136446 700__ $$aVega, Pablo
000136446 700__ $$aMartín, Dolores
000136446 700__ $$aPeña, Elena
000136446 700__ $$aVarela, Pilar
000136446 700__ $$aOlivares, Sonsoles
000136446 700__ $$aPajares, Ramón
000136446 700__ $$aLucendo, Alfredo J.
000136446 700__ $$aSesé, Eva
000136446 700__ $$aBotella Mateu, Belén
000136446 700__ $$aNos, Pilar
000136446 700__ $$aDomènech, Eugeni
000136446 700__ $$0(orcid)0000-0003-3970-5457$$aGarcía-López, Santiago$$uUniversidad de Zaragoza
000136446 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000136446 773__ $$g56, 12 (2024), 2060-2068$$pDig. liver dis.$$tDIGESTIVE AND LIVER DISEASE$$x1590-8658
000136446 8564_ $$s1719937$$uhttps://zaguan.unizar.es/record/136446/files/texto_completo.pdf$$yPostprint$$zinfo:eu-repo/date/embargoEnd/2025-06-15
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000136446 909CO $$ooai:zaguan.unizar.es:136446$$particulos$$pdriver
000136446 951__ $$a2024-12-20-12:05:35
000136446 980__ $$aARTICLE