000144616 001__ 144616
000144616 005__ 20240906103748.0
000144616 0247_ $$2doi$$a10.1016/j.arbres.2024.07.003
000144616 0248_ $$2sideral$$a139462
000144616 037__ $$aART-2024-139462
000144616 041__ $$aeng
000144616 100__ $$aSánchez-Azofra, Ana
000144616 245__ $$aApnea-Specific Pulse-Rate Response is Associated With Early Subclinical Atherosclerosis in Obstructive Sleep Apnea
000144616 260__ $$c2024
000144616 5060_ $$aAccess copy available to the general public$$fUnrestricted
000144616 5203_ $$aIntroduction
In patients with obstructive sleep apnea (OSA), novel metrics such as hypoxic burden (HB) and sleep apnea-specific pulse-rate response (ΔHR) may better correlate with cardiovascular diseases (CVD) than the apnea–hypopnea index (AHI). This manuscript aims to assess the correlation between ΔHR and HB with subclinical atherosclerosis in patients with OSA, testing the hypothesis that elevated ΔHR and HB are associated with subclinical atherosclerosis development.
Methods
In a prospective study, individuals aged 20–65 years with suspected OSA without known comorbidities were consecutively recruited and defined as OSA (AHI ≥ 5 events/h) or healthy controls. Using bilateral carotid ultrasonography, common carotid intima-media thickness (CIMT) was assessed and the identification of at least one atheromatous plaque defined the presence of subclinical atherosclerosis. ΔHR, and HB were derived from pulse-oximetry.
Results
We studied 296 patients of age 45 ± 10 years old, of whom 28% were women, and with a BMI of 30.3 ± 5.3 kg/m2. Overall, 245 had OSA and 51 were healthy controls. After controlling for confounding variables higher ΔHR but not HB, was associated with higher CIMT (p = 0.006) and higher time spent with oxygen saturation below 90% (T90) was associated with an increase in carotid atheroma plaques (p = 0.032). When stratifying OSA based on HB tertiles, we observed that within tertile 2 of HB, an increase in ΔHR was associated with larger CIMT (p = 0.017).
Conclusion
A higher ΔHR is associated with an increase in CIMT among adult patients with OSA. This study suggests that ΔHR could be a biomarker of risk for CVD in patients with OSA.
000144616 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII CD22-00033$$9info:eu-repo/grantAgreement/ES/ISCIII-FEDER-FIS/PI18-01524$$9info:eu-repo/grantAgreement/ES/ISCIII/PI21-01954
000144616 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000144616 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000144616 700__ $$aOrr, Jeremy E.
000144616 700__ $$0(orcid)0000-0002-5228-248X$$aSanz-Rubio, David
000144616 700__ $$aMarín-Oto, Marta$$uUniversidad de Zaragoza
000144616 700__ $$aAlarcón Sisamon, Sergio$$uUniversidad de Zaragoza
000144616 700__ $$0(orcid)0000-0001-6724-5158$$aVicente, Eugenio$$uUniversidad de Zaragoza
000144616 700__ $$aAncochea, Julio
000144616 700__ $$aSoriano, Joan B.
000144616 700__ $$aDeYoung, Pamela
000144616 700__ $$aAzarbarzin, Ali
000144616 700__ $$aMalhotra, Atul
000144616 700__ $$0(orcid)0000-0001-9096-2294$$aMarín, José M.$$uUniversidad de Zaragoza
000144616 7102_ $$11013$$2653$$aUniversidad de Zaragoza$$bDpto. Cirugía$$cÁrea Otorrinolaringología
000144616 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000144616 773__ $$g(2024), [8 pp.]$$pArch. bronconeumol.$$tArchivos de Bronconeumologia$$x0300-2896
000144616 8564_ $$s11006575$$uhttps://zaguan.unizar.es/record/144616/files/texto_completo.pdf$$yPostprint
000144616 8564_ $$s2720299$$uhttps://zaguan.unizar.es/record/144616/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000144616 909CO $$ooai:zaguan.unizar.es:144616$$particulos$$pdriver
000144616 951__ $$a2024-09-06-10:36:49
000144616 980__ $$aARTICLE