000144621 001__ 144621
000144621 005__ 20240829125213.0
000144621 0247_ $$2doi$$a10.1016/j.bbrc.2024.150521
000144621 0248_ $$2sideral$$a139398
000144621 037__ $$aART-2024-139398
000144621 041__ $$aeng
000144621 100__ $$aPramono, Didik
000144621 245__ $$aEndogenous retrovirus ERV-DC8 highly integrated in domestic cat populations is a replication-competent provirus
000144621 260__ $$c2024
000144621 5060_ $$aAccess copy available to the general public$$fUnrestricted
000144621 5203_ $$aEndogenous retroviruses (ERVs) are remnants of ancient retroviral infections in vertebrate genomes and are inherited by offspring. ERVs can produce pathogenic viruses through gene mutations or recombination. ERVs in domestic cats (ERV-DCs) generate feline leukemia virus subgroup D (FeLV-D) through viral recombination. Herein, we characterized the locus ERV-DC8, on chromosome B1, as an infectious replication-competent provirus. ERV-DC8 infected several cell lines, including human cells. Transmission electron microscopy of ERV-DC8 identified the viral release as a Gammaretrovirus. ERV-DC8 was identified as the FeLV-D viral interference group, with feline copper transporter 1 as its viral receptor. Insertional polymorphism analysis showed high ERV-DC8 integration in domestic cats. This study highlights the role, pathogenicity, and evolutionary relationships between ERVs and their hosts.
000144621 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc$$uhttp://creativecommons.org/licenses/by-nc/3.0/es/
000144621 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000144621 700__ $$aMuto, Yutaro
000144621 700__ $$aShimazu, Yo
000144621 700__ $$aDeshapriya, R.M.C.
000144621 700__ $$aMakundi, Isaac
000144621 700__ $$0(orcid)0000-0002-6770-3400$$aArnal, María Cruz$$uUniversidad de Zaragoza
000144621 700__ $$0(orcid)0000-0003-3289-4267$$aFernández de Luco, Daniel$$uUniversidad de Zaragoza
000144621 700__ $$aNgo, Minh Ha
000144621 700__ $$aMiyake, Ariko
000144621 700__ $$aNishigaki, Kazuo
000144621 7102_ $$11009$$2773$$aUniversidad de Zaragoza$$bDpto. Patología Animal$$cÁrea Sanidad Animal
000144621 773__ $$g738 (2024), 150521 [8 pp.]$$pBiochem. biophys. res. commun.$$tBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS$$x0006-291X
000144621 8564_ $$s5444689$$uhttps://zaguan.unizar.es/record/144621/files/texto_completo.pdf$$yVersión publicada
000144621 8564_ $$s2482646$$uhttps://zaguan.unizar.es/record/144621/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000144621 909CO $$ooai:zaguan.unizar.es:144621$$particulos$$pdriver
000144621 951__ $$a2024-08-29-10:45:56
000144621 980__ $$aARTICLE