144621 20260217205532.0 doi 10.1016/j.bbrc.2024.150521 sideral 139398 ART-2024-139398 eng Pramono, Didik Endogenous retrovirus ERV-DC8 highly integrated in domestic cat populations is a replication-competent provirus 2024 Access copy available to the general public Unrestricted Endogenous retroviruses (ERVs) are remnants of ancient retroviral infections in vertebrate genomes and are inherited by offspring. ERVs can produce pathogenic viruses through gene mutations or recombination. ERVs in domestic cats (ERV-DCs) generate feline leukemia virus subgroup D (FeLV-D) through viral recombination. Herein, we characterized the locus ERV-DC8, on chromosome B1, as an infectious replication-competent provirus. ERV-DC8 infected several cell lines, including human cells. Transmission electron microscopy of ERV-DC8 identified the viral release as a Gammaretrovirus. ERV-DC8 was identified as the FeLV-D viral interference group, with feline copper transporter 1 as its viral receptor. Insertional polymorphism analysis showed high ERV-DC8 integration in domestic cats. This study highlights the role, pathogenicity, and evolutionary relationships between ERVs and their hosts. info:eu-repo/semantics/openAccess by-nc https://creativecommons.org/licenses/by-nc/4.0/deed.es 2.2 2024 BIOPHYSICS 54 / 79 = 0.684 2024 Q3 T3 BIOCHEMISTRY & MOLECULAR BIOLOGY 241 / 320 = 0.753 2024 Q4 T3 0.748 2024 Biochemistry 2024 Q2 Biophysics 2024 Q2 Cell Biology 2024 Q3 Molecular Biology 2024 Q3 4.9 2024 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Muto, Yutaro Shimazu, Yo Deshapriya, R.M.C. Makundi, Isaac Arnal, María Cruz Universidad de Zaragoza (orcid)0000-0002-6770-3400 Fernández de Luco, Daniel Universidad de Zaragoza (orcid)0000-0003-3289-4267 Ngo, Minh Ha Miyake, Ariko Nishigaki, Kazuo 1009 773 Universidad de Zaragoza Dpto. Patología Animal Área Sanidad Animal 738 (2024), 150521 [8 pp.] Biochem. biophys. res. commun. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 0006-291X 5444689 http://zaguan.unizar.es/record/144621/files/texto_completo.pdf Versión publicada 2482646 http://zaguan.unizar.es/record/144621/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:144621 articulos driver 2026-02-17-20:32:57 ARTICLE