000144666 001__ 144666
000144666 005__ 20260210085415.0
000144666 0247_ $$2doi$$a10.1002/mds.29966
000144666 0248_ $$2sideral$$a139466
000144666 037__ $$aART-2024-139466
000144666 041__ $$aeng
000144666 100__ $$aPascual-Valdunciel, Alejandro
000144666 245__ $$aFrequency-selective suppression of essential tremor via transcutaneous spinal cord stimulation
000144666 260__ $$c2024
000144666 5060_ $$aAccess copy available to the general public$$fUnrestricted
000144666 5203_ $$aAbstractEssential tremor (ET) is a common debilitating condition, yet current treatments often fail to provide satisfactory relief. Transcutaneous spinal cord electrical stimulation (tSCS) has emerged as a potential noninvasive neuromodulation technique capable of disrupting the oscillatory activity underlying tremors.ObjectiveThis study aimed to investigate the potential of tSCS to disrupt tremor in a frequency‐dependent manner in a cohort of patients with ET.MethodsEighteen patients with ET completed the study. The experiment consisted of 60‐s postural tremor recording, during tSCS at tremor frequency, at 1 Hz, at 21 Hz, no stimulation, and trapezius stimulation. Tremor frequency and amplitude were analyzed and compared across the conditions.ResultsWe found tremor amplitude reduction at tremor frequency stimulation significant only during the second half of the stimulation. The same stimulation resulted in the highest number of responders. tSCS at 1 Hz showed a trend toward decreased tremor amplitude in the latter half of stimulation. tSCS at 21 Hz did not produce any significant alterations in tremor, whereas trapezius stimulation exacerbated it. Notably, during tremor frequency stimulation, a subgroup of responders exhibited consistent synchronization between tremor phase and delivered stimulation, indicating tremor entrainment.ConclusionsCervical tSCS holds promise for alleviating postural tremor in patients with ET when delivered at the subject's tremor frequency. The observed changes in tremor amplitude likely result from the modulation of spinal cord circuits by tSCS, which disrupts the oscillatory drive to muscles by affecting afferent pathways or spinal reflexes. However, the possibility of an interplay between spinal and supraspinal centers cannot be discounted. © 2024 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
000144666 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttps://creativecommons.org/licenses/by/4.0/deed.es
000144666 590__ $$a7.6$$b2024
000144666 592__ $$a2.988$$b2024
000144666 591__ $$aCLINICAL NEUROLOGY$$b19 / 286 = 0.066$$c2024$$dQ1$$eT1
000144666 593__ $$aNeurology (clinical)$$c2024$$dQ1
000144666 593__ $$aNeurology$$c2024$$dQ1
000144666 594__ $$a13.2$$b2024
000144666 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000144666 700__ $$0(orcid)0000-0001-8439-151X$$aIbáñez, Jaime$$uUniversidad de Zaragoza
000144666 700__ $$aRocchi, Lorenzo
000144666 700__ $$aSong, Joy
000144666 700__ $$aRothwell, John C.
000144666 700__ $$aBhatia, Kailash P.
000144666 700__ $$aFarina, Dario
000144666 700__ $$aLatorre, Anna
000144666 7102_ $$15008$$2800$$aUniversidad de Zaragoza$$bDpto. Ingeniería Electrón.Com.$$cÁrea Teoría Señal y Comunicac.
000144666 773__ $$g(2024), [13 pp.]$$pMov. disord.$$tMOVEMENT DISORDERS$$x0885-3185
000144666 8564_ $$s4063855$$uhttps://zaguan.unizar.es/record/144666/files/texto_completo.pdf$$yVersión publicada
000144666 8564_ $$s2504136$$uhttps://zaguan.unizar.es/record/144666/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000144666 909CO $$ooai:zaguan.unizar.es:144666$$particulos$$pdriver
000144666 951__ $$a2026-02-10-08:41:34
000144666 980__ $$aARTICLE