000144719 001__ 144719
000144719 005__ 20240906111328.0
000144719 0247_ $$2doi$$a10.1016/j.injury.2024.111736
000144719 0248_ $$2sideral$$a139506
000144719 037__ $$aART-2024-139506
000144719 041__ $$aeng
000144719 100__ $$aGarcía-Álvarez, Felicito
000144719 245__ $$aSerum levels of IL-6 and IL-10 on admission correlate with complications in elderly patients with hip fracture
000144719 260__ $$c2024
000144719 5203_ $$aAgeing may cause a progressive pro-inflammatory environment and alter functionality of different immune-cell populations. The aim of the present study is to examine the influence of certain serum immunological parameters on hospitalization stay and complications in patients who have suffered a hip fracture.
Patients and methods
A prospective study was carried out with 87 patients (63 women) presenting with either trochanteric femoral fracture or Garden IV displaced subcapital fracture. The average age was 84.43 ± 9, ranging from 65 to 104 years old. Data regarding different comorbidities were recorded at the time of arrival. The morning after patient's admission peripheral blood samples were obtained and a series of immunological parameters were determined: leukocyte formula, platelets count, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), IL-6 and IL-10 levels, T-lymphocytes count, number of cells/mm3 and percentages of CD3, CD4, CD8, CD3-/CD16/56+ (NK cells), and CD3-/CD19+ (B cells).
Results
IL-6 serum levels presented a positive and significant correlation with higher levels of CRP (p < 0.001), IL-10 (p = 0.002), and higher percentages of NK CD56+ cells (p = 0.046). IL-6 serum levels at hospitalization presented a positive and significant correlation with a longer hospitalization stay (p = 0.037). Hospitalization increased by 0.231 days for every 1 pg/mL above the IL-6 mean value (40.43 pg/mL). Lower serum IL-10 levels on admission were associated with the appearance of symptomatic urinary tract infection during hospitalization (p = 0.032). Higher number of CD19+ cells/mm3 presented a significant relationship with pneumonia (p = 0.018) and symptomatic urinary tract infection (p = 0.0019).
Conclusions
IL-6 serum levels on admission showed a positive and significant correlation with a longer hospitalization stay in elderly patients presenting with hip fracture. Lower levels of IL-10 in peripheral blood on admission were associated with symptomatic urinary tract infections. A higher number of CD19+ cells/mm³ was significantly associated with pneumonia and symptomatic urinary tract infection. These immunological variables on admission may serve as risk indicators of complications during hospitalization.
000144719 540__ $$9info:eu-repo/semantics/closedAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000144719 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000144719 700__ $$0(orcid)0000-0002-7420-1601$$aChueca-Marco, Álvaro$$uUniversidad de Zaragoza
000144719 700__ $$0(orcid)0000-0003-3043-147X$$aMartínez-Lostao, Luis$$uUniversidad de Zaragoza
000144719 700__ $$0(orcid)0000-0002-9962-6147$$aAso-Gonzalvo, María
000144719 700__ $$aEstella-Nonay, Rubén$$uUniversidad de Zaragoza
000144719 700__ $$0(orcid)0000-0003-4489-3130$$aAlbareda, Jorge$$uUniversidad de Zaragoza
000144719 7102_ $$11013$$2830$$aUniversidad de Zaragoza$$bDpto. Cirugía$$cÁrea Traumatología y Ortopedia
000144719 7102_ $$11011$$2566$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cÁrea Inmunología
000144719 773__ $$g(2024), 111736 [7 pp.]$$pInjury$$tInjury$$x0020-1383
000144719 8564_ $$s1129790$$uhttps://zaguan.unizar.es/record/144719/files/texto_completo.pdf$$yVersión publicada
000144719 8564_ $$s2387999$$uhttps://zaguan.unizar.es/record/144719/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000144719 909CO $$ooai:zaguan.unizar.es:144719$$particulos$$pdriver
000144719 951__ $$a2024-09-06-10:24:43
000144719 980__ $$aARTICLE