000144754 001__ 144754
000144754 005__ 20250923084445.0
000144754 0247_ $$2doi$$a10.1016/j.jbiomech.2024.112212
000144754 0248_ $$2sideral$$a139487
000144754 037__ $$aART-2024-139487
000144754 041__ $$aeng
000144754 100__ $$0(orcid)0000-0002-2360-8276$$aHernández-López, Patricia
000144754 245__ $$aImpact of hypertension and arterial wall expansion on transport properties and atherosclerosis progression
000144754 260__ $$c2024
000144754 5060_ $$aAccess copy available to the general public$$fUnrestricted
000144754 5203_ $$aThis study explored the impact of hypertension on atheroma plaque formation through a mechanobiological model. The model incorporates blood flow via the Navier–Stokes equation. Plasma flow through the endothelium is determined by Darcy’s law and the Kedem–Katchalsky equations, which consider the three-pore model utilized for substance flow across the endothelium. The behaviour of these substances within the arterial wall is described by convection–diffusion–reaction equations, while the arterial wall itself is modelled as a hyperelastic material using Yeoh’s model. To accurately evaluate hypertension’s influence, adjustments were made to incorporate wall compression-induced wall compaction by radial compression. This compaction impacts three key variables of the transport phenomena: diffusion, porosity, and permeability. Based on the obtained findings, we can conclude that hypertension significantly augments plaque growth, leading to an over 400% increase in plaque thickness. This effect persists regardless of whether wall mechanics are considered. Tortuosity, arterial wall permeability, and porosity have minimal impact on atheroma plaque growth under normal arterial pressure. However, the atheroma plaque growth changes dramatically in hypertensive cases. In such scenarios, the collective influence of all factors—tortuosity, permeability, and porosity—results in nearly a 20% increase in plaque growth. This emphasizes the importance of considering wall compression due to hypertension in patient studies, where elevated blood pressure and high cholesterol levels commonly coexist.
000144754 536__ $$9info:eu-repo/grantAgreement/ES/DGA-FSE/T24-20R$$9info:eu-repo/grantAgreement/ES/MICINN/BES-2017-080239$$9info:eu-repo/grantAgreement/ES/MICINN/PID2019-107517RB-I00$$9info:eu-repo/grantAgreement/ES/MICINN/PID2022-140219OB-I00$$9info:eu-repo/grantAgreement/ES/MINECO/RYC-2015-171562
000144754 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc$$uhttp://creativecommons.org/licenses/by-nc/3.0/es/
000144754 590__ $$a2.4$$b2024
000144754 592__ $$a0.8$$b2024
000144754 591__ $$aENGINEERING, BIOMEDICAL$$b78 / 124 = 0.629$$c2024$$dQ3$$eT2
000144754 593__ $$aRehabilitation$$c2024$$dQ1
000144754 591__ $$aBIOPHYSICS$$b47 / 79 = 0.595$$c2024$$dQ3$$eT2
000144754 593__ $$aBiophysics$$c2024$$dQ2
000144754 593__ $$aSports Science$$c2024$$dQ2
000144754 593__ $$aBiomedical Engineering$$c2024$$dQ2
000144754 593__ $$aOrthopedics and Sports Medicine$$c2024$$dQ2
000144754 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000144754 700__ $$0(orcid)0000-0001-8946-4829$$aLaita, Nicolás$$uUniversidad de Zaragoza
000144754 700__ $$0(orcid)0000-0002-8503-9291$$aCilla, Myriam$$uUniversidad de Zaragoza
000144754 700__ $$0(orcid)0000-0002-8375-0354$$aMartínez, Miguel Ángel$$uUniversidad de Zaragoza
000144754 700__ $$0(orcid)0000-0002-0664-5024$$aPeña, Estefanía$$uUniversidad de Zaragoza
000144754 7102_ $$15004$$2605$$aUniversidad de Zaragoza$$bDpto. Ingeniería Mecánica$$cÁrea Mec.Med.Cont. y Teor.Est.
000144754 773__ $$g174 (2024), 112212 [12 pp.]$$pJ. biomech.$$tJournal of Biomechanics$$x0021-9290
000144754 8564_ $$s2407067$$uhttps://zaguan.unizar.es/record/144754/files/texto_completo.pdf$$yVersión publicada
000144754 8564_ $$s2589847$$uhttps://zaguan.unizar.es/record/144754/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000144754 909CO $$ooai:zaguan.unizar.es:144754$$particulos$$pdriver
000144754 951__ $$a2025-09-22-14:53:47
000144754 980__ $$aARTICLE