144754 20260217205545.0 doi 10.1016/j.jbiomech.2024.112212 sideral 139487 ART-2024-139487 eng Hernández-López, Patricia (orcid)0000-0002-2360-8276 Impact of hypertension and arterial wall expansion on transport properties and atherosclerosis progression 2024 Access copy available to the general public Unrestricted This study explored the impact of hypertension on atheroma plaque formation through a mechanobiological model. The model incorporates blood flow via the Navier–Stokes equation. Plasma flow through the endothelium is determined by Darcy’s law and the Kedem–Katchalsky equations, which consider the three-pore model utilized for substance flow across the endothelium. The behaviour of these substances within the arterial wall is described by convection–diffusion–reaction equations, while the arterial wall itself is modelled as a hyperelastic material using Yeoh’s model. To accurately evaluate hypertension’s influence, adjustments were made to incorporate wall compression-induced wall compaction by radial compression. This compaction impacts three key variables of the transport phenomena: diffusion, porosity, and permeability. Based on the obtained findings, we can conclude that hypertension significantly augments plaque growth, leading to an over 400% increase in plaque thickness. This effect persists regardless of whether wall mechanics are considered. Tortuosity, arterial wall permeability, and porosity have minimal impact on atheroma plaque growth under normal arterial pressure. However, the atheroma plaque growth changes dramatically in hypertensive cases. In such scenarios, the collective influence of all factors—tortuosity, permeability, and porosity—results in nearly a 20% increase in plaque growth. This emphasizes the importance of considering wall compression due to hypertension in patient studies, where elevated blood pressure and high cholesterol levels commonly coexist. info:eu-repo/grantAgreement/ES/DGA-FSE/T24-20R info:eu-repo/grantAgreement/ES/MICINN/BES-2017-080239 info:eu-repo/grantAgreement/ES/MICINN/PID2019-107517RB-I00 info:eu-repo/grantAgreement/ES/MICINN/PID2022-140219OB-I00 info:eu-repo/grantAgreement/ES/MINECO/RYC-2015-171562 info:eu-repo/semantics/openAccess by-nc https://creativecommons.org/licenses/by-nc/4.0/deed.es 2.4 2024 ENGINEERING, BIOMEDICAL 78 / 124 = 0.629 2024 Q3 T2 BIOPHYSICS 47 / 79 = 0.595 2024 Q3 T2 0.8 2024 Rehabilitation 2024 Q1 Biophysics 2024 Q2 Sports Science 2024 Q2 Biomedical Engineering 2024 Q2 Orthopedics and Sports Medicine 2024 Q2 4.9 2024 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Laita, Nicolás Universidad de Zaragoza (orcid)0000-0001-8946-4829 Cilla, Myriam Universidad de Zaragoza (orcid)0000-0002-8503-9291 Martínez, Miguel Ángel Universidad de Zaragoza (orcid)0000-0002-8375-0354 Peña, Estefanía Universidad de Zaragoza (orcid)0000-0002-0664-5024 5004 605 Universidad de Zaragoza Dpto. Ingeniería Mecánica Área Mec.Med.Cont. y Teor.Est. 174 (2024), 112212 [12 pp.] J. biomech. Journal of Biomechanics 0021-9290 2407067 http://zaguan.unizar.es/record/144754/files/texto_completo.pdf Versión publicada 2589847 http://zaguan.unizar.es/record/144754/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:144754 articulos driver 2026-02-17-20:38:00 ARTICLE