000144780 001__ 144780
000144780 005__ 20250923084425.0
000144780 0247_ $$2doi$$a10.1002/cctc.202400817
000144780 0248_ $$2sideral$$a139568
000144780 037__ $$aART-2024-139568
000144780 041__ $$aeng
000144780 100__ $$aAscaso-Alegre, Christian$$uUniversidad de Zaragoza
000144780 245__ $$aChemoenzymatic One-Pot Cascade for the Construction of Asymmetric C-C and C-P Bonds via Formal C-H Activation
000144780 260__ $$c2024
000144780 5060_ $$aAccess copy available to the general public$$fUnrestricted
000144780 5203_ $$aThe integration of organocatalysis and enzyme catalysis in one‐pot cascade processes allows for the efficient construction of complex molecular architectures with high levels of stereocontrol. However, challenges related to reaction compatibility between both processes are often a limitation for the development of efficient synthetic routes. In this study, we describe the combination of an enzymatic aerobic oxidation followed by the squaramide‐mediated asymmetric formation of C−P and C−C bonds to access important building blocks such as chiral α‐hydroxyphosphonates and β‐nitro alcohols in good yields and enantiomeric ratios. This sequential process is conducted in a one‐pot fashion within a biphasic system and represents a pioneering example of a chemoenzymatic cascade involving aerobic biooxidation and an organocatalytic step operating under hydrogen‐bond activation mode and under mild reaction conditions.
000144780 536__ $$9info:eu-repo/grantAgreement/ES/AEI/PID2020-117455GB-I00$$9info:eu-repo/grantAgreement/ES/AEI/RED2022-134331-T$$9info:eu-repo/grantAgreement/ES/DGA/E07-23R$$9info:eu-repo/grantAgreement/ES/MICINN/PID2020-113351RA-I00$$9info:eu-repo/grantAgreement/ES/MICINN/RYC2021-032021-I$$9info:eu-repo/grantAgreement/EUR/MICINN/TED2021-130803B-I00
000144780 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000144780 590__ $$a3.9$$b2024
000144780 592__ $$a0.941$$b2024
000144780 591__ $$aCHEMISTRY, PHYSICAL$$b84 / 185 = 0.454$$c2024$$dQ2$$eT2
000144780 593__ $$aInorganic Chemistry$$c2024$$dQ1
000144780 593__ $$aPhysical and Theoretical Chemistry$$c2024$$dQ1
000144780 593__ $$aOrganic Chemistry$$c2024$$dQ1
000144780 593__ $$aCatalysis$$c2024$$dQ2
000144780 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000144780 700__ $$0(orcid)0000-0002-5244-9569$$aPérez Herrera, Raquel .
000144780 700__ $$0(orcid)0000-0002-3364-1512$$aMangas-Sánchez, Juan
000144780 7102_ $$11002$$2060$$aUniversidad de Zaragoza$$bDpto. Bioq.Biolog.Mol. Celular$$cÁrea Bioquímica y Biolog.Mole.
000144780 773__ $$g(2024), 7 pp.$$pChemCatChem$$tChemCatChem$$x1867-3880
000144780 8564_ $$s3494671$$uhttps://zaguan.unizar.es/record/144780/files/texto_completo.pdf$$yVersión publicada
000144780 8564_ $$s3079794$$uhttps://zaguan.unizar.es/record/144780/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000144780 909CO $$ooai:zaguan.unizar.es:144780$$particulos$$pdriver
000144780 951__ $$a2025-09-22-14:38:43
000144780 980__ $$aARTICLE