000144790 001__ 144790
000144790 005__ 20250923084418.0
000144790 0247_ $$2doi$$a10.3390/ijms25158285
000144790 0248_ $$2sideral$$a139586
000144790 037__ $$aART-2024-139586
000144790 041__ $$aeng
000144790 100__ $$0(orcid)0000-0002-4665-9674$$aHerrera-Marcos, Luis V.$$uUniversidad de Zaragoza
000144790 245__ $$aLipoprotein Lipidomics as a Frontier in Non-Alcoholic Fatty Liver Disease Biomarker Discovery
000144790 260__ $$c2024
000144790 5060_ $$aAccess copy available to the general public$$fUnrestricted
000144790 5203_ $$aNon-alcoholic fatty liver disease (NAFLD) is a progressive liver disease characterized by the build-up of fat in the liver of individuals in the absence of alcohol consumption. This condition has become a burden in modern societies aggravated by the lack of appropriate predictive biomarkers (other than liver biopsy). To better understand this disease and to find appropriate biomarkers, a new technology has emerged in the last two decades with the ability to explore the unmapped role of lipids in this disease: lipidomics. This technology, based on the combination of chromatography and mass spectrometry, has been extensively used to explore the lipid metabolism of NAFLD. In this review, we aim to summarize the knowledge gained through lipidomics assays exploring tissues, plasma, and lipoproteins from individuals with NAFLD. Our goal is to identify common features and active pathways that could facilitate the finding of a reliable biomarker from this field. The most frequent observation was a variable decrease (1–9%) in polyunsaturated fatty acids in phospholipids and non-esterified fatty acids in NAFLD patients, both in plasma and liver. Additionally, a reduction in phosphatidylcholines is a common feature in the liver. Due to the scarcity of studies, further research is needed to properly detect lipoprotein, plasma, and tissue lipid signatures of NAFLD etiologies, and NAFLD subtypes, and to define the relevance of this technology in disease management strategies in the push toward personalized medicine.
000144790 536__ $$9info:eu-repo/grantAgreement/ES/CIBERObn/CB06-03-1012$$9info:eu-repo/grantAgreement/ES/DGA/B03-23R$$9info:eu-repo/grantAgreement/ES/DGA/B16-23R$$9info:eu-repo/grantAgreement/ES/ISCIII/PI22-01366$$9info:eu-repo/grantAgreement/ES/ISCIII/PMP21-00094$$9info:eu-repo/grantAgreement/ES/MCINN/PID2022-136414OB-I00
000144790 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000144790 590__ $$a4.9$$b2024
000144790 592__ $$a1.273$$b2024
000144790 591__ $$aBIOCHEMISTRY & MOLECULAR BIOLOGY$$b72 / 319 = 0.226$$c2024$$dQ1$$eT1
000144790 593__ $$aMedicine (miscellaneous)$$c2024$$dQ1
000144790 591__ $$aCHEMISTRY, MULTIDISCIPLINARY$$b70 / 239 = 0.293$$c2024$$dQ2$$eT1
000144790 593__ $$aPhysical and Theoretical Chemistry$$c2024$$dQ1
000144790 593__ $$aComputer Science Applications$$c2024$$dQ1
000144790 593__ $$aInorganic Chemistry$$c2024$$dQ1
000144790 593__ $$aSpectroscopy$$c2024$$dQ1
000144790 593__ $$aOrganic Chemistry$$c2024$$dQ1
000144790 593__ $$aMolecular Biology$$c2024$$dQ2
000144790 593__ $$aCatalysis$$c2024$$dQ2
000144790 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000144790 700__ $$0(orcid)0000-0002-8982-3737$$aArbones-Mainar, Jose M.
000144790 700__ $$0(orcid)0000-0002-8251-8457$$aOsada, Jesús$$uUniversidad de Zaragoza
000144790 7102_ $$11003$$2027$$aUniversidad de Zaragoza$$bDpto. Anatom.Histolog.Humanas$$cArea Anatom.Embriol.Humana
000144790 7102_ $$11002$$2060$$aUniversidad de Zaragoza$$bDpto. Bioq.Biolog.Mol. Celular$$cÁrea Bioquímica y Biolog.Mole.
000144790 773__ $$g25, 15 (2024), 8285 [25 pp.]$$pInt. j. mol. sci.$$tInternational Journal of Molecular Sciences$$x1661-6596
000144790 8564_ $$s1258977$$uhttps://zaguan.unizar.es/record/144790/files/texto_completo.pdf$$yVersión publicada
000144790 8564_ $$s2774332$$uhttps://zaguan.unizar.es/record/144790/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
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000144790 951__ $$a2025-09-22-14:34:11
000144790 980__ $$aARTICLE