000144794 001__ 144794
000144794 005__ 20240906111329.0
000144794 0247_ $$2doi$$a10.3390/biomedicines12081780
000144794 0248_ $$2sideral$$a139498
000144794 037__ $$aART-2024-139498
000144794 041__ $$aeng
000144794 100__ $$aSopeña-Pinilla, Maria
000144794 245__ $$aRetinochoroidal Vascular Changes in Long-Term Type 1 Diabetic Patients Assessed by Optic Coherence Tomography Angiography
000144794 260__ $$c2024
000144794 5060_ $$aAccess copy available to the general public$$fUnrestricted
000144794 5203_ $$aTo study retinal and choriocapillaris (CC) alterations using optical coherence tomography angiography (OCTA) in long-term type 1 diabetic (DM1) patients without diabetic retinopathy (DR). Seventy-eight eyes from 78 well-controlled DM1 patients diagnosed at least 15 years prior and 130 eyes of 130 healthy subjects were included in a cross-sectional descriptive study. Six eyes were excluded from the DM1 group. OCTA with Deep Range Imaging (DRI)-Triton swept source (SS)-OCT was performed. Statistically significant differences were found in all areas of the superficial capillary plexus (SCP), with lower values in DM1 patients. Differences were noted in all quadrants of the deep capillary plexus (DCP) except for the central area. Significant changes in CC blood flow were only found in the center. The foveal avascular zone (FAZ) area and diameters in the SCP were significantly different, while the DCP FAZ area was similar in both groups. Disease duration and microalbuminuria correlated negatively with some SCP areas and positively with FAZ values. Anatomical evaluation revealed microaneurysms in both plexuses, FAZ modifications, and areas lacking blood perfusion. Long-term type 1 diabetic patients without DR display microvascular abnormalities affecting retinal and CC blood perfusion, along with anatomical changes in retinal blood vessels.
000144794 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI20-00740
000144794 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000144794 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000144794 700__ $$0(orcid)0000-0003-2710-1875$$aOrduna-Hospital, Elvira$$uUniversidad de Zaragoza
000144794 700__ $$aDiaz-Barreda, Maria D.
000144794 700__ $$aBoned-Murillo, Ana
000144794 700__ $$0(orcid)0000-0003-1234-9712$$aFernandez-Espinosa, Guisela
000144794 700__ $$aArias-Alvarez, Marta
000144794 700__ $$0(orcid)0000-0002-2987-6351$$aAcha-Perez, Javier
000144794 700__ $$0(orcid)0000-0002-5621-1937$$aSanchez-Cano, Ana$$uUniversidad de Zaragoza
000144794 700__ $$0(orcid)0000-0003-0349-9997$$aPinilla, Isabel$$uUniversidad de Zaragoza
000144794 7102_ $$11013$$2646$$aUniversidad de Zaragoza$$bDpto. Cirugía$$cÁrea Oftalmología
000144794 7102_ $$12002$$2647$$aUniversidad de Zaragoza$$bDpto. Física Aplicada$$cÁrea Óptica
000144794 773__ $$g12, 8 (2024), 1780 [10 pp.]$$tBiomedicines$$x2227-9059
000144794 8564_ $$s1360928$$uhttps://zaguan.unizar.es/record/144794/files/texto_completo.pdf$$yVersión publicada
000144794 8564_ $$s2804699$$uhttps://zaguan.unizar.es/record/144794/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000144794 909CO $$ooai:zaguan.unizar.es:144794$$particulos$$pdriver
000144794 951__ $$a2024-09-06-10:26:11
000144794 980__ $$aARTICLE