144810 20240912134240.0 doi 10.1111/cns.12314 sideral 95854 ART-2014-95854 eng Fayed, N Changes in metabolites after treatment with memantine in fibromyalgia. A double-blind randomized controlled trial with magnetic resonance spectroscopy with a 6-month follow-up. 2014 Aim: To evaluate the efficacy of memantine on metabolite levels in different areas of the brain and to determine whether changes in metabolite levels correlate with clinical variables in Fibromyalgia (FM) patients. Methods: Doubled-blind parallel randomized controlled trial. Twenty-five patients diagnosed with FM were enrolled in the study. Patients were administered questionnaires on pain, anxiety, depression, quality of life, and cognitive impairment, and single-voxel MRS of the brain was performed. All assessments were performed at baseline and after 6 months of treatment with memantine or placebo. Results: Patients treated with memantine exhibited a significant increase in the glutamate (P = 0.010), glutamate/creatine ratio (P = 0.013), combined glutamate + glutamine (P = 0.016) and total N-acetyl-aspartate (NAA+NAAG) (P = 0.034) in the posterior cingulate cortex compared with those on placebo. Furthermore, the memantine group exhibited increases in creatine (P = 0.013) and choline (Cho) (P = 0.025) in the right posterior insula and also a correlation between choline and the Fibromyalgia Impact Questionnaire (FIQ) in the posterior insula (P = 0.050) was observed. Conclusion: Memantine treatment resulted in an increase in cerebral metabolism in FM patients, suggesting its utility for the treatment of the illness. info:eu-repo/semantics/closedAccess All rights reserved http://www.europeana.eu/rights/rr-f/ 3.931 2014 PHARMACOLOGY & PHARMACY 43 / 255 = 0.169 2014 Q1 T1 NEUROSCIENCES 67 / 251 = 0.267 2014 Q2 T1 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Oliván-Blázquez, B Universidad de Zaragoza (orcid)0000-0001-6565-9699 Herrera-Mercadal, P Universidad de Zaragoza (orcid)0000-0003-2088-4272 Puebla-Guedea, M (orcid)0000-0002-8862-7240 Pérez-Yus, MC Universidad de Zaragoza (orcid)0000-0001-5566-9746 Andrés, E López del Hoyo, Y Universidad de Zaragoza (orcid)0000-0002-1690-4130 Magallon, R Universidad de Zaragoza (orcid)0000-0002-5494-6550 Viguera, L Garcia-Campayo, J. Universidad de Zaragoza (orcid)0000-0002-3797-4218 4009 740 Universidad de Zaragoza Dpto. Psicología y Sociología Área Psicología Social 4009 730 Universidad de Zaragoza Dpto. Psicología y Sociología Área Psicología Básica 1007 610 Universidad de Zaragoza Dpto. Medicina, Psiqu. y Derm. Area Medicina 0 X Universidad de Zaragoza Estudios propios Estudios Propios Dpto.M.Ps.y D 1007 745 Universidad de Zaragoza Dpto. Medicina, Psiqu. y Derm. Area Psiquiatría 4009 680 Universidad de Zaragoza Dpto. Psicología y Sociología Área Person.Eval.Trat.Psicoló. 20, 11 (2014), 999-1007 CNS Neuroscience & Therapeutics CNS Neuroscience & Therapeutics 1755-5930 870028 http://zaguan.unizar.es/record/144810/files/texto_completo.pdf Postprint 1287775 http://zaguan.unizar.es/record/144810/files/texto_completo.jpg?subformat=icon icon Postprint oai:zaguan.unizar.es:144810 articulos driver 2024-09-12-13:05:00 ARTICLE