000144881 001__ 144881
000144881 005__ 20240912134241.0
000144881 0247_ $$2doi$$a10.1016/j.artmed.2024.102962
000144881 0248_ $$2sideral$$a139708
000144881 037__ $$aART-2024-139708
000144881 041__ $$aeng
000144881 100__ $$aTorres-Martos, Álvaro
000144881 245__ $$aMultiomics and eXplainable artificial intelligence for decision support in insulin resistance early diagnosis: a pediatric population-based longitudinal study
000144881 260__ $$c2024
000144881 5060_ $$aAccess copy available to the general public$$fUnrestricted
000144881 5203_ $$aPediatric obesity can drastically heighten the risk of cardiometabolic alterations later in life, with insulin resistance standing as the cornerstone linking adiposity to the increased cardiovascular risk. Puberty has been pointed out as a critical stage after which obesity-associated insulin resistance is more difficult to revert. Timely prediction of insulin resistance in pediatric obesity is therefore vital for mitigating the risk of its associated comorbidities. The construction of effective and robust predictive systems for a complex health outcome like insulin resistance during the early stages of life demands the adoption of longitudinal designs for more causal inferences, and the integration of factors of varying nature involved in its onset. In this work, we propose an eXplainable Artificial Intelligence-based decision support pipeline for early diagnosis of insulin resistance in a longitudinal cohort of 90 children. For that, we leverage multi-omics (genomics and epigenomics) and clinical data from the pre-pubertal stage. Different data layers combinations, pre-processing techniques (missing values, feature selection, class imbalance, etc.), algorithms, training procedures were considered following good practices for Machine Learning. SHapley Additive exPlanations were provided for specialists to understand both the decision-making mechanisms of the system and the impact of the features on each automatic decision, an essential issue in high-risk areas such as this one where system decisions may affect people’s lives. The system showed a relevant predictive ability (AUC and G-mean of 0.92). A deep exploration, both at the global and the local level, revealed promising biomarkers of insulin resistance in our population, highlighting classical markers, such as Body Mass Index z-score or leptin/adiponectin ratio, and novel ones such as methylation patterns of relevant genes, such as HDAC4, PTPRN2, MATN2, RASGRF1 and EBF1. Our findings highlight the importance of integrating multi-omics data and following eXplainable Artificial Intelligence trends when building decision support systems.
000144881 536__ $$9info:eu-repo/grantAgreement/ES/AEI/FJC2021-046952-I$$9info:eu-repo/grantAgreement/EC/HORIZON EUROPE/101080219/EU/Preventing lifetime obesity by early risk-factor identification, prognosis and intervention/eprObes$$9info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI20-00924$$9info:eu-repo/grantAgreement/ES/ISCIII/PI20-00563$$9info:eu-repo/grantAgreement/ES/ISCIII/PI20-00711$$9info:eu-repo/grantAgreement/ES/ISCIII/PI20-00988$$9info:eu-repo/grantAgreement/ES/ISCIII/PI23-00028$$9info:eu-repo/grantAgreement/ES/ISCIII/PI23-00129$$9info:eu-repo/grantAgreement/ES/ISCIII/PI23-00165$$9info:eu-repo/grantAgreement/ES/ISCIII/PI23-00191$$9info:eu-repo/grantAgreement/ES/ISCIII/PI23-01032$$9info:eu-repo/grantAgreement/ES/MICIN-ISCIII/FI23-00042$$9info:eu-repo/grantAgreement/ES/MICIN-ISCIII/IFI17-00048$$9info:eu-repo/grantAgreement/ES/MICIN-ISCIII/IFI22-00013
000144881 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000144881 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000144881 700__ $$aAnguita-Ruiz, Augusto
000144881 700__ $$aBustos-Aibar, Mireia
000144881 700__ $$aRamírez-Mena, Alberto
000144881 700__ $$aArteaga, María
000144881 700__ $$0(orcid)0000-0002-0902-387X$$aBueno, Gloria$$uUniversidad de Zaragoza
000144881 700__ $$aLeis, Rosaura
000144881 700__ $$aAguilera, Concepción M.
000144881 700__ $$aAlcalá, Rafael
000144881 700__ $$aAlcalá-Fdez, Jesús
000144881 7102_ $$11011$$2670$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cÁrea Pediatría
000144881 773__ $$g156 (2024), 102962 [14 pp.]$$pArtif. intell. med.$$tARTIFICIAL INTELLIGENCE IN MEDICINE$$x0933-3657
000144881 8564_ $$s1725797$$uhttps://zaguan.unizar.es/record/144881/files/texto_completo.pdf$$yVersión publicada
000144881 8564_ $$s2713474$$uhttps://zaguan.unizar.es/record/144881/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000144881 909CO $$ooai:zaguan.unizar.es:144881$$particulos$$pdriver
000144881 951__ $$a2024-09-12-13:06:24
000144881 980__ $$aARTICLE