000144942 001__ 144942
000144942 005__ 20240920135617.0
000144942 0247_ $$2doi$$a10.3390/muscles3030022
000144942 0248_ $$2sideral$$a139741
000144942 037__ $$aART-2024-139741
000144942 041__ $$aeng
000144942 100__ $$0(orcid)0000-0003-0454-6302$$aLecina, Miguel$$uUniversidad de Zaragoza
000144942 245__ $$aExertional rhabdomyolysis and ultra-trail races: a systematic review highlighting the significant impact of eccentric load
000144942 260__ $$c2024
000144942 5060_ $$aAccess copy available to the general public$$fUnrestricted
000144942 5203_ $$aExertional rhabdomyolysis (ER) is a condition where muscle breakdown occurs after intense and unaccustomed exercise in healthy individuals. It is characterized by muscle pain, weakness, and myoglobinuria, potentially leading to acute kidney injury and worsening the patients’ prognosis. Ultra-trail races (UT) necessitate high energy and extreme muscular exertion, which can result in significant muscle breakdown, leading to ER and elevated biomarkers such as creatine kinase (CK) and lactate dehydrogenase (LDH). These races involve longer durations and both uphill and downhill elevations, with the latter causing more muscle damage. This systematic review aims to analyse the effect of downhill elevation (at least 1000 m) in UT on muscle and liver damage biomarkers. We conducted a systematic review of four electronic databases (Pubmed, Web of Science, Scopus, and Sportdiscus) based on PRISMA guidelines for systematic reviews. We included a total of 15 articles out of 6670 published between January 2005 and March 2024. The total population sample included 348 subjects, comprising 294 men (84.48%) and 54 women (15.52%) with a mean age of 39.82 ± 6.89 years. Only one subject (0.28%) was diagnosed with ER. The median increase in CK post vs. pre was 5370.63 ± 7289.71%, LDH post vs. pre was 311.20 ± 164.4%, and liver damage biomarkers aspartate transaminase (AST) and alanine aminotransferase (ALT) obtained mean increases of 1009.94 ± 743.97% and 207.02 ± 92.84%, respectively. No liver injury cases were reported. These findings suggest that ER is often misdiagnosed in UT and may result in acute kidney injury under certain circumstances. Therefore, it is crucial to define and prepare the characteristics required for ultra runners to safely participate in these extreme races.
000144942 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000144942 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000144942 700__ $$0(orcid)0009-0002-1869-6854$$aCastellar-Otín, Carlos$$uUniversidad de Zaragoza
000144942 700__ $$0(orcid)0000-0002-6829-0775$$aGarcía-Giménez, Alejandro$$uUniversidad de Zaragoza
000144942 700__ $$0(orcid)0000-0003-1121-6408$$aPradas, Francisco$$uUniversidad de Zaragoza
000144942 7102_ $$13001$$2187$$aUniversidad de Zaragoza$$bDpto. Expres.Music.Plást.Corp.$$cÁrea Didáctica Expres.Corporal
000144942 7102_ $$11006$$2245$$aUniversidad de Zaragoza$$bDpto. Fisiatría y Enfermería$$cÁrea Educación Física y Depor.
000144942 773__ $$g3, 3 (2024), 242-258$$pMuscles$$tMuscles$$x2813-0413
000144942 8564_ $$s1739299$$uhttps://zaguan.unizar.es/record/144942/files/texto_completo.pdf$$yVersión publicada
000144942 8564_ $$s2838104$$uhttps://zaguan.unizar.es/record/144942/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000144942 909CO $$ooai:zaguan.unizar.es:144942$$particulos$$pdriver
000144942 951__ $$a2024-09-20-13:01:03
000144942 980__ $$aARTICLE