000144961 001__ 144961 000144961 005__ 20240920135617.0 000144961 0247_ $$2doi$$a10.3390/life14091152 000144961 0248_ $$2sideral$$a139736 000144961 037__ $$aART-2024-139736 000144961 041__ $$aeng 000144961 100__ $$0(orcid)0000-0003-1234-9712$$aFernández-Espinosa, Guisela 000144961 245__ $$aTracking macular sensitivity and inner retinal thickness in long-term Type 1 Diabetes: a five-year prospective examination in patients without diabetic retinopathy 000144961 260__ $$c2024 000144961 5060_ $$aAccess copy available to the general public$$fUnrestricted 000144961 5203_ $$aThe aim of the study is to compare macular sensitivity and retinal thickness in patients with long-term type 1 diabetes mellitus (DM1) without diabetic retinopathy (DR) after 5 years of follow-up. Thirty-two eyes from 32 long-term DM1 patients without DR were included. All participants underwent a complete ophthalmological examination, including microperimetry and spectral domain optical coherence tomography (SD-OCT). The data were compared with results from 5 years prior. The mean age of the DM1 patients was 43.19 ± 10.17 years, with a mean disease duration of 29.84 ± 8.98 years and good glycemic control. In 2023, patients exhibited a significantly worse best corrected visual acuity (BCVA) compared to 2018 (p < 0.001). DM1 patients did not show statistically significant changes in macular sensitivity over the 5-year follow-up period. Macular integrity showed significant differences between the two time points (p = 0.045). Retinal thickness showed significant differences, particularly in inner retinal layers (IRL) across most of the ETDRS areas. Long-term DM1 patients without DR lesions showed worsened macular integrity and a lower BCVA in 2023. Additionally, they displayed significant alterations in retinal thicknesses, especially in the IRL, between 2018 and 2023. These findings suggest that even in the absence of visible DR, long-term DM1 patients may experience subclinical retinal changes and functional deterioration over time, highlighting the importance of regular monitoring for the early detection and management of potential complications. 000144961 536__ $$9info:eu-repo/grantAgreement/ES/DGA/B08-23R$$9info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI20-00740 000144961 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/ 000144961 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000144961 700__ $$0(orcid)0000-0003-2710-1875$$aOrduna-Hospital, Elvira$$uUniversidad de Zaragoza 000144961 700__ $$aSopeña-Pinilla, María 000144961 700__ $$aArias-Álvarez, Marta 000144961 700__ $$aBoned-Murillo, Ana 000144961 700__ $$aDíaz-Barreda, María Dolores 000144961 700__ $$0(orcid)0000-0002-5621-1937$$aSánchez-Cano, Ana$$uUniversidad de Zaragoza 000144961 700__ $$0(orcid)0000-0003-0349-9997$$aPinilla, Isabel$$uUniversidad de Zaragoza 000144961 7102_ $$11013$$2646$$aUniversidad de Zaragoza$$bDpto. Cirugía$$cÁrea Oftalmología 000144961 7102_ $$12002$$2647$$aUniversidad de Zaragoza$$bDpto. Física Aplicada$$cÁrea Óptica 000144961 773__ $$g14, 9 (2024), 1152 [14 pp.]$$pLife (Basel)$$tLife$$x2075-1729 000144961 8564_ $$s2212308$$uhttps://zaguan.unizar.es/record/144961/files/texto_completo.pdf$$yVersión publicada 000144961 8564_ $$s2726073$$uhttps://zaguan.unizar.es/record/144961/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000144961 909CO $$ooai:zaguan.unizar.es:144961$$particulos$$pdriver 000144961 951__ $$a2024-09-20-13:01:26 000144961 980__ $$aARTICLE