000144971 001__ 144971
000144971 005__ 20260217205555.0
000144971 0247_ $$2doi$$a10.1002/ejhf.3390
000144971 0248_ $$2sideral$$a139804
000144971 037__ $$aART-2024-139804
000144971 041__ $$aeng
000144971 100__ $$aCobo Marcos, Marta
000144971 245__ $$aEfficacy and safety of hypertonic saline therapy in ambulatory patients with heart failure: The SALT-HF trial
000144971 260__ $$c2024
000144971 5203_ $$aAimsCombination of hypertonic saline solution (HSS) with intravenous loop diuretics has been suggested to improve diuretic response in patients hospitalized for heart failure (HF). The efficacy and safety of this approach in the ambulatory setting remain unexplored.Methods and resultsIn this multicentre, double‐blind, randomized study, we allocated ambulatory patients with worsening heart failure (WHF) to a 1‐h infusion of intravenous furosemide (ivFurosemide)‐HSS versus ivFurosemide. The primary endpoint was the volume of diuresis at 3 h. Secondary endpoints included 3‐h natriuresis and weight variation, 7‐day congestion data, kidney function and electrolytes, and 30‐day clinical events. Overall, 167 participants (median age: 81 years, 30.5% female) were randomized across 13 sites between December 2020 and March 2023. There were no differences in 3‐h diuresis between treatments (ivFurosemide‐HSS: 1099 ml vs. ivFurosemide: 1103 ml, p = 0.963), 3‐h natriuresis (∆ +2.642 mEq/L, p = 0.559), or 3‐h weight (∆ +0.012 kg, p = 0.920). Patients in the ivFurosemide‐HSS arm experienced significant weight decrease at 7 days (Δ −0.586 kg, p = 0.048). There were no between‐treatment differences in clinical congestion score, biomarkers, inferior vena cava diameter, or the presence of lung ultrasound B‐lines. At 30 days, 26.5% of the patients in the ivFurosemide‐HSS group versus 33.3% in the ivFurosemide group experienced WHF (hazard ratio 0.76, p = 0.330). The incidence of death from any cause or HF hospitalization was 6% of patients in the ivFurosemide‐HSS group and 8.3% of patients in the ivFurosemide group (hazard ratio 0.69, p = 0.521). The incidence of worsening kidney function or metabolic derangements was not significantly different in the two arms.ConclusionsA single infusion of ivFurosemide‐HSS did not improve 3‐h diuresis or congestion parameters in patients with ambulatory WHF. This therapy showed an appropriate safety profile.
000144971 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII/PI20-00689
000144971 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000144971 590__ $$a10.8$$b2024
000144971 592__ $$a5.559$$b2024
000144971 591__ $$aCARDIAC & CARDIOVASCULAR SYSTEMS$$b12 / 231 = 0.052$$c2024$$dQ1$$eT1
000144971 593__ $$aCardiology and Cardiovascular Medicine$$c2024$$dQ1
000144971 594__ $$a22.0$$b2024
000144971 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000144971 700__ $$ade la Espriella, Rafael
000144971 700__ $$aComín-Colet, Josep
000144971 700__ $$aZegrí-Reiriz, Isabel
000144971 700__ $$0(orcid)0000-0002-4769-7154$$aRubio Gracia, Jorge$$uUniversidad de Zaragoza
000144971 700__ $$aMorales-Rull, Jose Luis
000144971 700__ $$aLlàcer, Pau
000144971 700__ $$aDíez-Villanueva, Pablo
000144971 700__ $$aJiménez-Marrero, Santiago
000144971 700__ $$ade Juan Bagudá, Javier
000144971 700__ $$aOrtiz Cortés, Carolina
000144971 700__ $$aRestrepo-Córdoba, Maria Alejandra
000144971 700__ $$aGoirigolzarri-Artaza, Josebe
000144971 700__ $$aGarcía-Pinilla, Jose Manuel
000144971 700__ $$aBarrios, Elvira
000144971 700__ $$adel Prado Díaz, Susana
000144971 700__ $$aMontero Hernández, Esther
000144971 700__ $$0(orcid)0000-0002-2338-7637$$aSanchez-Marteles, Marta$$uUniversidad de Zaragoza
000144971 700__ $$aNúñez, Julio
000144971 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000144971 773__ $$g26, 10 (2024), 2118-2128$$pEur. j. heart fail.$$tEuropean Journal of Heart Failure$$x1388-9842
000144971 8564_ $$s5870674$$uhttps://zaguan.unizar.es/record/144971/files/texto_completo.pdf$$yVersión publicada
000144971 8564_ $$s2636182$$uhttps://zaguan.unizar.es/record/144971/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000144971 909CO $$ooai:zaguan.unizar.es:144971$$particulos$$pdriver
000144971 951__ $$a2026-02-17-20:42:06
000144971 980__ $$aARTICLE