000145019 001__ 145019
000145019 005__ 20260112133359.0
000145019 0247_ $$2doi$$a10.1063/5.0206341
000145019 0248_ $$2sideral$$a139783
000145019 037__ $$aART-2024-139783
000145019 041__ $$aeng
000145019 100__ $$0(orcid)0000-0002-5701-1670$$aSerrano, Sergio$$uUniversidad de Zaragoza
000145019 245__ $$aUnderstanding the role of B cells in CAR T-cell therapy in leukemia through a mathematical model
000145019 260__ $$c2024
000145019 5060_ $$aAccess copy available to the general public$$fUnrestricted
000145019 5203_ $$aChimeric antigen receptor T (CAR T) cell therapy has been proven to be successful against a variety of leukemias and lymphomas. This paper undertakes an analytical and numerical study of a mathematical model describing the competition of CAR T, leukemia, tumor, and B cells. Considering its significance in sustaining anti-CD19 CAR T-cell stimulation, a B-cell source term is integrated into the model. Through stability and bifurcation analyses, the potential for tumor eradication, contingent on the continuous influx of B cells, has been revealed, showing a transcritical bifurcation at a critical B-cell input. Additionally, an almost heteroclinic cycle between equilibrium points is identified, providing a theoretical basis for understanding disease relapse. Analyzing the oscillatory behavior of the system, the time-dependent dynamics of CAR T cells and leukemic cells can be approximated, shedding light on the impact of initial tumor burden on therapeutic outcomes. In conclusion, the study provides insights into CAR T-cell therapy dynamics for acute lymphoblastic leukemias, offering a theoretical foundation for clinical observations and suggesting avenues for future immunotherapy modeling research.
000145019 536__ $$9info:eu-repo/grantAgreement/ES/AEI/PID2022-140341OB-I00$$9info:eu-repo/grantAgreement/ES/AEI/PID2022-140451OB-I00$$9info:eu-repo/grantAgreement/ES/DGA/E24-23R$$9info:eu-repo/grantAgreement/ES/DGA/LMP 94-21
000145019 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttps://creativecommons.org/licenses/by/4.0/deed.es
000145019 590__ $$a3.2$$b2024
000145019 592__ $$a0.77$$b2024
000145019 591__ $$aPHYSICS, MATHEMATICAL$$b5 / 61 = 0.082$$c2024$$dQ1$$eT1
000145019 593__ $$aPhysics and Astronomy (miscellaneous)$$c2024$$dQ1
000145019 591__ $$aMATHEMATICS, APPLIED$$b13 / 343 = 0.038$$c2024$$dQ1$$eT1
000145019 593__ $$aMathematical Physics$$c2024$$dQ2
000145019 593__ $$aStatistical and Nonlinear Physics$$c2024$$dQ2
000145019 593__ $$aApplied Mathematics$$c2024$$dQ2
000145019 593__ $$aMedicine (miscellaneous)$$c2024$$dQ2
000145019 594__ $$a4.8$$b2024
000145019 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000145019 700__ $$0(orcid)0000-0002-8089-343X$$aBarrio, Roberto$$uUniversidad de Zaragoza
000145019 700__ $$aMartínez-Rubio, Álvaro
000145019 700__ $$aBelmonte-Beitia, Juan
000145019 700__ $$aPérez-García, Víctor M.
000145019 7102_ $$12005$$2595$$aUniversidad de Zaragoza$$bDpto. Matemática Aplicada$$cÁrea Matemática Aplicada
000145019 773__ $$g34, 8 (2024), [15 pp.]$$pChaos$$tCHAOS$$x1054-1500
000145019 8564_ $$s16691288$$uhttps://zaguan.unizar.es/record/145019/files/texto_completo.pdf$$yPostprint
000145019 8564_ $$s3078365$$uhttps://zaguan.unizar.es/record/145019/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000145019 909CO $$ooai:zaguan.unizar.es:145019$$particulos$$pdriver
000145019 951__ $$a2026-01-12-13:23:11
000145019 980__ $$aARTICLE