000145074 001__ 145074
000145074 005__ 20250923084438.0
000145074 0247_ $$2doi$$a10.3390/jcm13185579
000145074 0248_ $$2sideral$$a139871
000145074 037__ $$aART-2024-139871
000145074 041__ $$aeng
000145074 100__ $$0(orcid)0000-0003-4071-1467$$aLuesma, María José$$uUniversidad de Zaragoza
000145074 245__ $$aEnteric Nervous System and Its Relationship with Neurological Diseases
000145074 260__ $$c2024
000145074 5060_ $$aAccess copy available to the general public$$fUnrestricted
000145074 5203_ $$aThe enteric nervous system (ENS) is a fundamental component of the gastrointestinal system, composed of a vast network of neurons and glial cells. It operates autonomously but is interconnected with the central nervous system (CNS) through the vagus nerve. This communication, known as the gut–brain axis, influences the bidirectional communication between the brain and the gut. Background/Objectives: This study aimed to review neurological pathologies related to the ENS. Methods: To this end, a comprehensive literature search was conducted in the “PubMed” database. Articles available in “free format” were selected, applying the filters “Humans” and limiting the search to publications from the last ten years. Results: The ENS has been linked to various neurological diseases, from autism spectrum disorder to Parkinson’s disease including neurological infection with the varicella zoster virus (VZV), even sharing pathologies with the CNS. This finding suggests that the ENS could serve as an early diagnostic marker or therapeutic target for neurological diseases. Gastrointestinal symptoms often precede CNS symptoms, and the ENS’s accessibility aids in diagnosis and treatment. Parkinson’s patients may show intestinal lesions up to twenty years before CNS symptoms, underscoring the potential for early diagnosis. However, challenges include developing standardized diagnostic protocols and the uneven distribution of dopaminergic neurons in the ENS. Continued research is needed to explore the ENS’s potential in improving disease prognosis. Conclusions: The ENS is a promising area for early diagnosis and therapeutic development. Nevertheless, it is essential to continue research in this area, especially to gain a deeper understanding of its organization, function, and regenerative capacity.
000145074 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000145074 590__ $$a2.9$$b2024
000145074 592__ $$a0.919$$b2024
000145074 591__ $$aMEDICINE, GENERAL & INTERNAL$$b65 / 332 = 0.196$$c2024$$dQ1$$eT1
000145074 593__ $$aMedicine (miscellaneous)$$c2024$$dQ1
000145074 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000145074 700__ $$aLópez-Marco, Liberto
000145074 700__ $$0(orcid)0000-0002-2787-9671$$aMonzón, Marta$$uUniversidad de Zaragoza
000145074 700__ $$0(orcid)0000-0002-1275-2600$$aSantander, Sonia$$uUniversidad de Zaragoza
000145074 7102_ $$11003$$2443$$aUniversidad de Zaragoza$$bDpto. Anatom.Histolog.Humanas$$cArea Histología
000145074 7102_ $$11003$$2027$$aUniversidad de Zaragoza$$bDpto. Anatom.Histolog.Humanas$$cArea Anatom.Embriol.Humana
000145074 7102_ $$11012$$2315$$aUniversidad de Zaragoza$$bDpto. Farmac.Fisiol.y Med.L.F.$$cÁrea Farmacología
000145074 773__ $$g13, 18 (2024), 5579 [16 pp.]$$pJ. clin.med.$$tJournal of Clinical Medicine$$x2077-0383
000145074 8564_ $$s1504145$$uhttps://zaguan.unizar.es/record/145074/files/texto_completo.pdf$$yVersión publicada
000145074 8564_ $$s2629045$$uhttps://zaguan.unizar.es/record/145074/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000145074 909CO $$ooai:zaguan.unizar.es:145074$$particulos$$pdriver
000145074 951__ $$a2025-09-22-14:48:15
000145074 980__ $$aARTICLE