000145094 001__ 145094
000145094 005__ 20260113074413.0
000145094 0247_ $$2doi$$a10.1021/acs.joc.4c01839
000145094 0248_ $$2sideral$$a139948
000145094 037__ $$aART-2024-139948
000145094 041__ $$aeng
000145094 100__ $$aTrujillo-Sierra, José
000145094 245__ $$aAsymmetric remote aldol cyclization reaction to synthesize trifluoromethylated heterospirocyclic frameworks
000145094 260__ $$c2024
000145094 5060_ $$aAccess copy available to the general public$$fUnrestricted
000145094 5203_ $$aThe highly enantioselective organocatalytic synthesis of dihydropyran spirocyclic compounds bearing di- and trifluoromethyl groups by aldol cyclization reaction via trienamine using cyclic 2,5-dienones and different di- and trifluoromethylketones is described. Using a bifunctional aminothiourea catalyst, trifluoromethyl-functionalized dihydropyran spirocyclic products were obtained with good yields and enantioselectivities. Subsequent transformation with H2 and Pd/C has allowed the synthesis of the tetrahydropyran structure with three stereocenters. The plausible reaction mechanism was investigated by computational methods.
000145094 536__ $$9info:eu-repo/grantAgreement/ES/AEI/RED2022-134331-T$$9info:eu-repo/grantAgreement/ES/MICINN/RED2022-134287-T$$9info:eu-repo/grantAgreement/ES/MINECO/CTQ2017-82935-P$$9info:eu-repo/grantAgreement/ES/MINECO-FEDER/PID2019-107268GB-I00
000145094 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000145094 590__ $$a3.6$$b2024
000145094 592__ $$a0.737$$b2024
000145094 591__ $$aCHEMISTRY, ORGANIC$$b10 / 57 = 0.175$$c2024$$dQ1$$eT1
000145094 593__ $$aOrganic Chemistry$$c2024$$dQ2
000145094 594__ $$a6.1$$b2024
000145094 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000145094 700__ $$aSansano, José Miguel
000145094 700__ $$aPardos, Jorge$$uUniversidad de Zaragoza
000145094 700__ $$0(orcid)0000-0003-3433-6701$$aTejero, Tomás$$uUniversidad de Zaragoza
000145094 700__ $$0(orcid)0000-0002-2202-3460$$aMerino, Pedro$$uUniversidad de Zaragoza
000145094 700__ $$aRetamosa, María de Gracia
000145094 7102_ $$12013$$2765$$aUniversidad de Zaragoza$$bDpto. Química Orgánica$$cÁrea Química Orgánica
000145094 773__ $$g89, 18 (2024), 13654-13660$$pJ. org. chem.$$tJournal of Organic Chemistry$$x0022-3263
000145094 8564_ $$s2171653$$uhttps://zaguan.unizar.es/record/145094/files/texto_completo.pdf$$yPostprint$$zinfo:eu-repo/date/embargoEnd/2025-09-05
000145094 8564_ $$s2588531$$uhttps://zaguan.unizar.es/record/145094/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint$$zinfo:eu-repo/date/embargoEnd/2025-09-05
000145094 909CO $$ooai:zaguan.unizar.es:145094$$particulos$$pdriver
000145094 951__ $$a2026-01-12-13:14:40
000145094 980__ $$aARTICLE