000145102 001__ 145102
000145102 005__ 20240926122722.0
000145102 0247_ $$2doi$$a10.1159/000539504
000145102 0248_ $$2sideral$$a139888
000145102 037__ $$aART-2024-139888
000145102 041__ $$aeng
000145102 100__ $$aBambó, María Pilar
000145102 245__ $$aA four-years retrospective study: Clinical outcomes of XEN45 in patients with glaucoma
000145102 260__ $$c2024
000145102 5060_ $$aAccess copy available to the general public$$fUnrestricted
000145102 5203_ $$aIntroduction: To evaluate the long-term effectiveness and safety of XEN45 implant, either alone or in combination with cataract surgery, in patients with glaucoma.
Methods: Retrospective and single center study conducted on consecutive patients who underwent a XEN45 implant, either alone or in combination with cataract surgery, between November 2016 and October 2021. The primary endpoint was the mean IOP lowering from preoperative values.
Results: Among the 230 screened patients, 206 eyes (176 patients) were included. Fifty-three (25.7%) eyes had undergone XEN-alone and 153 (74.3%) eyes had undergone a combined procedure (XEN+Phacoemulsification). The mean preoperative intraocular pressure (IOP) was significantly higher in the XEN-alone (22.2±5.9 mmHg) than in the XEN+Phaco (19.8±4.5 mmHg) group (p=0.0035). In the overall study population, the mean preoperative IOP was significantly lowered from 20.5±5.0 mmHg to 15.8±4.4 at year-4, p<0.0001. The mean preoperative (95% CI) IOP was significantly lowered from 22.2 (20.6 to 23.8) mmHg and 19.8 (19.1 to 20.6) mmHg to 15.6 (12.2 to 16.9) mmHg and 15.9 (15.2 to 16.5) mmHg at year-4 in the XEN-alone and XEN+Phaco groups, respectively (p<0.0001 each, respectively). The number of ocular hypotensive medications was significant reduced from 2.6±1.0 drugs to 1.3±1.3 drugs, with no significant differences between XEN-alone and XEN+Phaco groups (p=0.1671). On the first postoperative day, 62 (30.1%) eyes presented some type of complication. Fifteen (7.3%) eyes underwent a needling procedure.
Conclusion: XEN45, either alone or in combination with phacoemulsification, significantly lowered the IOP and reduce the need of ocular hypotensive medication in the long-term.
000145102 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000145102 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000145102 700__ $$aTello, Álvaro
000145102 700__ $$aVicente, María José$$uUniversidad de Zaragoza
000145102 700__ $$aMallén, Víctor$$uUniversidad de Zaragoza
000145102 700__ $$aBiescas-Merino, Andrés
000145102 700__ $$aYáñez, Jacobo
000145102 700__ $$0(orcid)0000-0003-0558-065X$$aIsanta, Carlos$$uUniversidad de Zaragoza
000145102 700__ $$aFerrández, Blanca
000145102 700__ $$aFuentemilla, Enrique
000145102 700__ $$aPérez-Oliván, Susana
000145102 700__ $$0(orcid)0000-0001-8563-3437$$aGüerri, Noemí$$uUniversidad de Zaragoza
000145102 700__ $$0(orcid)0000-0002-6745-7668$$aLarrosa, José Manuel$$uUniversidad de Zaragoza
000145102 700__ $$0(orcid)0000-0002-1402-3129$$aPolo, Vicente$$uUniversidad de Zaragoza
000145102 700__ $$0(orcid)0000-0003-2389-8282$$aPablo, Luis Emilio$$uUniversidad de Zaragoza
000145102 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000145102 7102_ $$11013$$2646$$aUniversidad de Zaragoza$$bDpto. Cirugía$$cÁrea Oftalmología
000145102 7102_ $$11013$$2817$$aUniversidad de Zaragoza$$bDpto. Cirugía$$cÁrea Urología
000145102 773__ $$g67 (2024), 478–487$$pOphthalmic res.$$tOPHTHALMIC RESEARCH$$x0030-3747
000145102 8564_ $$s440342$$uhttps://zaguan.unizar.es/record/145102/files/texto_completo.pdf$$yVersión publicada
000145102 8564_ $$s1988899$$uhttps://zaguan.unizar.es/record/145102/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000145102 909CO $$ooai:zaguan.unizar.es:145102$$particulos$$pdriver
000145102 951__ $$a2024-09-26-10:59:31
000145102 980__ $$aARTICLE