000145142 001__ 145142
000145142 005__ 20241003094705.0
000145142 0247_ $$2doi$$a10.1016/j.jnutbio.2017.10.005
000145142 0248_ $$2sideral$$a103467
000145142 037__ $$aART-2018-103467
000145142 041__ $$aeng
000145142 100__ $$aBaila-Rueda, Lucía
000145142 245__ $$aCholesterol oversynthesis markers define familial combined hyperlipidemia versus other genetic hypercholesterolemias independently of body weight
000145142 260__ $$c2018
000145142 5203_ $$aPrimary hypercholesterolemia of genetic origin, negative for mutations in LDLR, APOB, PCSK9 and APOE genes (non-FH GH), and familial combined hyperlipidemia (FCHL) are polygenic genetic diseases that occur with hypercholesterolemia, and both share a very high cardiovascular risk. In order to better characterize the metabolic abnormalities associated with these primary hypercholesterolemias, we used noncholesterol sterols, as markers of cholesterol metabolism, to determine their potential differences. Hepatic cholesterol synthesis markers (desmosterol and lanosterol) and intestinal cholesterol absorption markers (sitosterol and campesterol) were determined in non-FH GH (n=200), FCHL (n=100) and genetically defined heterozygous familial hypercholesterolemia subjects (FH) (n=100) and in normolipidemic controls (n=100). FCHL subjects had lower cholesterol absorption and higher cholesterol synthesis than non-FH GH, FH and controls (P<.001). When noncholesterol sterols were adjusted by body mass index (BMI), FCHL subjects had higher cholesterol synthesis than non-FG GH, FH and controls (P<.001). An increase in BMI was accompanied by increased cholesterol synthesis and decreased cholesterol absorption in non-FH GH, FH and controls. However, this association between BMI and cholesterol synthesis was not observed in FCHL. Non-high-density-lipoprotein cholesterol showed a positive correlation with cholesterol synthesis markers similar to that of BMI in non-FH GH, FH and normolipemic controls, but there was no correlation in FCHL. These results suggest that FCHL and non-FH GH have different mechanisms of production. Cholesterol synthesis and absorption are dependent of BMI in non-FH GH, but cholesterol synthesis is increased as a pathogenic mechanism in FCHL independently of age, gender, APOE and BMI.
000145142 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/IIS16-0114$$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI13-02507$$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI15-01983
000145142 540__ $$9info:eu-repo/semantics/closedAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000145142 590__ $$a4.49$$b2018
000145142 591__ $$aNUTRITION & DIETETICS$$b13 / 85 = 0.153$$c2018$$dQ1$$eT1
000145142 591__ $$aBIOCHEMISTRY & MOLECULAR BIOLOGY$$b63 / 294 = 0.214$$c2018$$dQ1$$eT1
000145142 592__ $$a1.428$$b2018
000145142 593__ $$aBiochemistry$$c2018$$dQ1
000145142 593__ $$aClinical Biochemistry$$c2018$$dQ1
000145142 593__ $$aNutrition and Dietetics$$c2018$$dQ1
000145142 593__ $$aMolecular Biology$$c2018$$dQ1
000145142 593__ $$aEndocrinology, Diabetes and Metabolism$$c2018$$dQ1
000145142 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000145142 700__ $$aCenarro, Ana
000145142 700__ $$0(orcid)0000-0002-9647-0108$$aLamiquiz-Moneo, Itziar
000145142 700__ $$0(orcid)0000-0002-1894-1621$$aPérez-Calahorra, Sofía
000145142 700__ $$aBea, Ana M.
000145142 700__ $$aMarco-Benedí, Victoria
000145142 700__ $$0(orcid)0000-0001-9142-0737$$aJarauta, Estíbaliz$$uUniversidad de Zaragoza
000145142 700__ $$0(orcid)0000-0001-6650-8294$$aMateo-Gallego, Rocío$$uUniversidad de Zaragoza
000145142 700__ $$0(orcid)0000-0001-7043-0952$$aCiveira, Fernando$$uUniversidad de Zaragoza
000145142 7102_ $$11006$$2255$$aUniversidad de Zaragoza$$bDpto. Fisiatría y Enfermería$$cÁrea Enfermería
000145142 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000145142 773__ $$g53 (2018), 48-57$$pJ. nutr. biochem.$$tJournal of Nutritional Biochemistry$$x0955-2863
000145142 8564_ $$s1739722$$uhttps://zaguan.unizar.es/record/145142/files/texto_completo.pdf$$yVersión publicada
000145142 8564_ $$s2923369$$uhttps://zaguan.unizar.es/record/145142/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000145142 909CO $$ooai:zaguan.unizar.es:145142$$particulos$$pdriver
000145142 951__ $$a2024-10-03-08:55:44
000145142 980__ $$aARTICLE