000145194 001__ 145194 000145194 005__ 20241003094705.0 000145194 0247_ $$2doi$$a10.1016/j.jad.2024.09.036 000145194 0248_ $$2sideral$$a139982 000145194 037__ $$aART-2024-139982 000145194 041__ $$aeng 000145194 100__ $$aPeláez, Trinidad 000145194 245__ $$aEfficacy of the unified protocol for transdiagnostic treatment of comorbid emotional disorders in patients with ultra high risk for psychosis: Results of a randomized controlled trial 000145194 260__ $$c2024 000145194 5060_ $$aAccess copy available to the general public$$fUnrestricted 000145194 5203_ $$aBackground The most common reason for help-seeking in ultra-high risk (UHR) for psychosis patients is comorbid symptoms, mainly anxiety and depression. However, psychological interventions are mainly focused on subthreshold psychotic symptoms. There is a growing push to include transdiagnostic therapies in specialized intervention teams for psychosis in young people. The Unified Protocol for the Transdiagnostic Treatment of Emotional Disorders (UP) has demonstrated efficacy in emotional disorders, and its application has recently expanded to other pathologies such as borderline personality disorder (BPD) and bipolar disorder (BD). Methods This pilot study was conducted with 36 patients with UHR for psychosis and symptoms of comorbid emotional disorders who were receiving treatment in an early intervention programme for psychosis. This is a randomised control trial (RCT) with two conditions: treatment as usual (TAU) with the group and online application of the UP (UP+TAU) (n = 18) and TAU (n = 18). Evaluations were conducted at baseline, after treatment, and at the three-month follow-up. Results Comorbid anxiety and depression symptoms improved significantly in patients in the UP+TAU group compared to those in the TAU. Significant improvements in negative affect, emotional dysregulation, neuroticism, extraversion, functioning, and quality of life were also observed, and satisfaction with the intervention was high. Conclusions UP may be an acceptable and effective intervention for the treatment of symptoms of comorbid emotional disorders in patients with UHR for psychosis. Limitations The sample size was small, and further studies are needed to test this intervention with larger samples of patients with UHR for psychosis with emotional comorbidities. 000145194 536__ $$9info:eu-repo/grantAgreement/ES/DGA/S31-23R 000145194 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc$$uhttp://creativecommons.org/licenses/by-nc/3.0/es/ 000145194 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000145194 700__ $$aLópez-Carrilero, Raquel 000145194 700__ $$aEspinosa, Victoria 000145194 700__ $$aBalsells, Sol 000145194 700__ $$aOchoa, Susana 000145194 700__ $$0(orcid)0000-0002-7293-318X$$aOsma, Jorge$$uUniversidad de Zaragoza 000145194 7102_ $$14009$$2680$$aUniversidad de Zaragoza$$bDpto. Psicología y Sociología$$cÁrea Person.Eval.Trat.Psicoló. 000145194 773__ $$g367 (2024), 934-943$$pJ. affect. disord.$$tJournal of Affective Disorders$$x0165-0327 000145194 8564_ $$s826731$$uhttps://zaguan.unizar.es/record/145194/files/texto_completo.pdf$$yVersión publicada 000145194 8564_ $$s2282516$$uhttps://zaguan.unizar.es/record/145194/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000145194 909CO $$ooai:zaguan.unizar.es:145194$$particulos$$pdriver 000145194 951__ $$a2024-10-03-08:56:50 000145194 980__ $$aARTICLE